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FLASH GENE
Symbol MYLK2 contributors: - updated : 26-07-2006
HGNC name myosin light chain kinase 2, skeletal muscle
HGNC id 16243
Location 20q13.31      Physical location : 30.407.177 - 30.422.500
Synonym symbol(s) KMLC, MLCK, skMLCK
EC.number 2.7.1.117
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a protein kinase domain
HOMOLOGY
Homologene
FAMILY ser/thr protein kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microfilament
text colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils
basic FUNCTION
  • calcium/calmodulin-dependent serine/threonine kinase phosphorylating myosin light chain
  • implicated in the level of global muscle contraction and cardiac function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • calcium Ca2+
  • calmodulin
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    gain-in-function mutation in cardiac hypertrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS