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FLASH GENE

Symbol

MYLK2

contributors: - updated : 26-07-2006

HGNC name	myosin light chain kinase 2, skeletal muscle
HGNC id	16243

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a protein kinase domain

HOMOLOGY

Homologene

FAMILY

ser/thr protein kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microfilament
text	colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils

basic FUNCTION	calcium/calmodulin-dependent serine/threonine kinase phosphorylating myosin light chain
	implicated in the level of global muscle contraction and cardiac function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	calcium Ca2+
	calmodulin

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function gain-in-function mutation in cardiac hypertrophy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS