Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MYB contributors: mct - updated : 14-12-2016
HGNC name v-myb myeloblastosis viral oncogene homolog (avian)
HGNC id 7545
Location 6q23.3      Physical location : 135.502.452 - 135.540.313
Synonym name
  • avian myeloblastosis viral (v-myb) oncogene homolog
  • c-myb protein (140 AA)
  • Synonym symbol(s) c-myb, Cmyb, c-myb_CDS, efg
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 37.86 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    VNN1 6q23-q24 vanin 1 VNN3 6q23-q24 vanin 3 VNN2 6q23-q24 vanin 2 C6orf192 6q22.3-q23.3 chromosome 6 open reading frame 192 RPS12 6q23.1 ribosomal protein S12 LOC134870 6q23.1 similar to 60S ribosomal protein L23a EYA4 6q23 eyes absent homolog 4 (Drosophila) MGC34034 6q23.2 hypothetical protein MGC34034 TCF21 6q23-q24 transcription factor 21 FLJ35700 6q23.2 hypothetical protein FLJ35700 TBPL1 6q22.1-q22.3 TBP-like 1 SLC2A12 6q23.2 solute carrier family 2 (facilitated glucose transporter), member 12 SGK 6q23 serum/glucocorticoid regulated kinase LOC391971 6 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 LOC391972 6 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein FAM8A6P 6q23 family with sequence similarity 8, member A6 pseudogene LOC154094 6q23.2 similar to Protein CGI-27 (C21orf19-like protein) ALDH8A1 6q24.1-q25.1 aldehyde dehydrogenase 8 family, member A1 HBS1L 6q23-q24 HBS1-like (S. cerevisiae) MYB 6q23.3-q24 v-myb myeloblastosis viral oncogene homolog (avian) AHI1 6q23.2 Abelson helper integration site LOC391973 6 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PDE7B 6q23-q24 phosphodiesterase 7B DUFD1 6q23.2 DUF729 domain containing 1 BTF 6q23 DUF729 domain containing 1 MAP7 6q23.3 microtubule-associated protein 7 MAP3K5 6q22.33 mitogen-activated protein kinase kinase kinase 5 PEX7 6q21-q22.2 peroxisomal biogenesis factor 7 SLC35D3 6q23.2 solute carrier family 35, member D3 IL20RA 6q23.3 interleukin 20 receptor, alpha IL22RA2 6q24-q25.1 interleukin 22 receptor, alpha 2 IFNGR1 6q23-q24 interferon gamma receptor 1 OLIG3 6q23.3 oligodendrocyte transcription factor 3 LOC391974 6 similar to RIKEN cDNA 5730434I03 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3369 - 758 - 1990 2202948
    isoform 4
    16 - 3681 - 761 - 1990 2202948
    isoform 1
    15 - 3309 - 637 - 1990 2202948
    isoform 3
    15 - 3342 - 640 - 1990 2202948
    isoform 2
    14 - 3060 - 555 - 1990 2202948
    isoform 5
    16 - 3630 - 745 - 1990 2202948
    isoform 6
    14 - 3204 - 603 - 1990 2202948
    isoform 7
    14 - 3210 - 605 - 1990 2202948
    isoform 8
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Blood/Hematopoieticprogenitor cell
    Digestiveameloblast Homo sapiens
    Digestiveodontoblast Homo sapiens
    not specificfibroblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three functional domains responsible for DNA binding, transcriptional activation, and negative regulation
  • DNA-binding domain in the N terminus consists of three imperfect tandem repeats of 5152 amino acids and binds to the DNA sequence 5'-AACNG-3'
  • centrally located transcriptional activation domain binds to the transcriptional coactivator CBP
  • a WD40 domain, negative regulator in the C-terminal portion of MYB interacts with the corepressors TRIM28 and ZMYND11
  • HOMOLOGY
    interspecies homolog to avian myeloblastosis viral (v-myb) oncogene
    homolog to murine Myb (91.0pc)
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the proliferation of immature hematopoietic cells, as well as hematopoietic cell differentiation
  • inducing DNA binding
  • effector of estrogen/ER signaling and have a functional role in breast cancer
  • controls SNAI2 transcription in tumor cells of different origin
  • functional relationship between MYB and metastasis-associated SNAI2 in hematopoietic and non-hematopoietic cancer cells
  • role for MYB at the hub of ER- and HER2-dependent pathways in mammary carcinogenesis
  • critical role of MYB in promoting ERBIN transcription in G2/M phase
  • MYB- activity is regulated by various post-translational modifications
  • potential integration of MYB into regulatory networks during hard-tissue differentiation and mineralization
  • role for MYB in the regulation of stem cells
  • is identified as a novel regulator of PAX7 in early neural crest development
  • has an early, crucial and conserved role in multiciliogenesis, and it promotes likely a novel S-like phase in which centriole amplification occurs uncoupled from DNA synthesis
  • acts in a conserved pathway downstream of Notch signaling and multicilin, a protein related to the S-phase regulator geminin, and upstream of FOXJ1
  • is involved in regulating the differentiation program of myogenic progenitor cells as its expression blocks myoblast fusion
  • MYB and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like globin genes in the adult erythroid environment
  • transcription factor MYB is a key regulator that permits early multilineage differentiation of airway epithelial cells
  • key regulator of hematopoiesis, including having critical roles in hematopoietic stem cells (HSCs)
  • specific role for MYB in KRT14+ epithelial cells in the preservation of adult skin integrity and function
  • may play a specific role in hard tissue formation
  • transcription factor involved in the regulation and promotion of endochondral bone formation
  • is a transcription factor with multifaceted target regulation depending on cell type
  • transcription factor regulating the expression of a wide array of genes involved in cellular functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    unique MYB-DHRS2-MDM2-TP53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • target of estrogen/ER signaling
  • interacting with MAF (modulation of MYB activity may be an important mechanism for the control of gene transcription during hematopoietic cell development)
  • cooperates with CASP8AP2 in foci associated with active POLR2A, leading to enhancement of MYB-dependent gene activation
  • target genes including MYC, BCL2 and GBX2 which are involved in cell cycle control, blockage of apoptosis, and growth and differentiation control, respectively
  • interacting with HIPK1
  • HBS1L-MYB intergenic interval associated with elevated HbF levels
  • activates SNAI2 expression through a transcriptional mechanism in embryonic kidney, colon carcinoma, chronic myeloid leukemia and neuroblastoma cells
  • PIAS1 is a common partner for two cancer-related nuclear factors, MYB and CASP8AP2 (functional cooperation between CASP8AP2 and PIAS1 in the enhancement of MYB activity in active nuclear foci)
  • interaction of MYB with MYB site in the ERBIN promoter was significantly enhanced in G2/M phase
  • FBXW5 enhanced sumoylation of nuclear MYB and induced the localization of MYB to nuclear dot-like domains
  • FBXW5 enhances sumoylation of MYB in the nucleus, which suppresses MYB activity
  • FBXW5-mediated sumoylation of MYB may enhance the repression of some MYB target gene
  • MYB is identified as a novel regulator of PAX7 in early neural crest development
  • KIX domains of CREBBP, and especially EP300, are principal mediators of MYB-dependent gene activation and repression that is required for definitive hematopoiesis
  • PIAS1 causes activation or repression of MYB dependent target genes
  • PIAS1 acts as a "protein inhibitor of activated MYB" in the absence of SUMOylation while, in its presence, PIAS1 behaves as a "protein activator of repressed MYB"
  • MYB expression is critical for myeloid leukemia development induced by SETBP1 activation
  • TGFB1I1 is a novel interaction partner of the nuclear kinase HIPK1 and TGFB1I1, like HIPK1, also interacts with the transcription factor MYB
  • TGFB1I1 and HIPK1 assist MYB in recruiting the coactivator and acetyltransferase EP300 to chromatin
  • MAZ is essential to bypass MYB promoter repression by RB1 family members and to induce MYB expression
  • cell & other
    REGULATION
    Other phosphorylated and degraded in response to Wnt1 signaling
    phosphorylated by HIPK1, repressing the ability to activate MIM1 in haematopoietic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    contribute to leukemogenesis
    tumoral     --over  
    at relatively high levels in at least two epithelial tumors: colon and breast cancer
    tumoral     --over  
    in T cell acute lymphoblastic leukemia
    constitutional     --over  
    promotes nuclear accumulation of DHRS2, which is able to support P53 stabilization and activation
    tumoral fusion translocation    
    t(6;9)(q23.3;p22.3) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck results in fusions encoding chimeric transcripts predominantly consisting of MYB exon 14 linked to the last coding exon(s) of NFIB
    constitutional   deletion    
    in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression
    tumoral fusion      
    MYB-GATA1 fusion gene in acute basophilic leukemia
    tumoral     --over  
    aberrantly overexpressed in pancreatic cancer cells and acts as a key determinant of pancreatic tumour growth and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a therapeutic target in human T-ALL
    ANIMAL & CELL MODELS