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FLASH GENE
Symbol MUC6 contributors: mct - updated : 07-03-2013
HGNC name mucin 6, oligomeric mucus/gel-forming
HGNC id 7517
Location 11p15.5      Physical location : 1.012.823 - 1.036.706
Synonym name mucin 6, gastric
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, opposite orientation
text clustered to chromosome 11p15.5 with three other secreted gel-forming mucins, MUC5B, MUC2, and MUC5AC
STRUCTURE 23.88 kb     33 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • transcription start site with a TATA box at -35 to -29bp
  • a putative NFkappaB consensus sequence at -173 to -164bp, and putative Sp family binding sites at -530 to -521 and -847 to -838bp
    • MAPPING cloned Y linked   status provisional
    Map pter - HRAS - MUC6 /MUCX - MUC2 - MUC5AC - MUC5B - IGF2 - cen
    Authors Pigny (96), Velcich (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 8003 - 2439 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   specific Homo sapiensAdult
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extended array of simple tandem repeats flanked by cysteine-rich subdomains
  • N terminal WWFD domains
  • C terminal region much shorter, with reduced cysteine residues
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • major secreted mucins of the digestive tract, involved in renal morphogenesis processes
  • contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries
  • critical protective function in the normal stomach, pancreas and duodenum
  • may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFkappaB and Sp family members
    Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal neoplasia and in intraepithelial cancer of the pancreas
    tumoral     --other  
    expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma
    tumoral     --over  
    in pancreatic intraductal papillary-mucinous neoplasm
    Susceptibility to H pylori infection
    Variant & Polymorphism other Short MUC6 alleles are associated with H pylori infection
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS