| basic FUNCTION
| involved in cytoskeletal organization by sequestering actin monomers |
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both a SHH-responsive gene and a new member of the pathway that modulates GLI responses during growth and tumorigenesis  |
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prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells |
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required at the basal body of mesenchymal cells for cilia maintenance, SHH responsiveness, and de novo hair follicle formation |
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promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin |
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involved in the Shh signaling pathway in the developing hair follicle and in basal cell carcinomas of the skin |
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acts as a scaffold protein that interacts with multiple partners to regulate actin dynamics |
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may act as a scaffold protein to activate actin assembly |
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function as a cytoskeletal protein with a role in cancer metastasis |
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tissue-specific regulator of plasma membrane dynamics, whose altered expression levels have been linked to cancer metastasis |
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modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia |
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required for neural fold elevation and apical constriction along with cell polarization and elongation in both the superficial and deep layers of the anterior neural plate |
