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FLASH GENE
Symbol MTSS1 contributors: mct - updated : 05-09-2016
HGNC name metastasis suppressor 1
HGNC id 20443
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
of PDIA3, LYAR, NOP14, NCALD and MTSS1 genes in the ovarian cancer with poor prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • independent predictor for tumor recurrence and overall survival in patients with cholangiocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    important target for cancer therapy in oesophageal squamous cell carcinoma
    ANIMAL & CELL MODELS
  • Mtss1-deficient mice displayed a severe urinary concentration defect caused by compromised integrity of kidney epithelia intercellular junctions, which led to bone abnormalities and end-stage renal failure
  • Mim-deficient mice displayed altered glutamatergic synaptic transmission and compatible behavioral defects