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FLASH GENE
Symbol MTMR9 contributors: mct/pgu - updated : 01-06-2017
HGNC name myotubularin related protein 9
HGNC id 14596
Location 8p23.1      Physical location : 11.141.999 - 11.185.652
Synonym name myotubularin related protein 8
Synonym symbol(s) MTMR8, LIP-STYX, C8orf9, MGC126672
EC.number 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 43.65 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure 10 cm distal to MTMR7
MAPPING cloned Y linked Y status provisional
Physical map
LOC346702 8p23.1 similar to tryptophan/serine protease RP1L1 8p23 retinitis pigmentosa 1-like 1 LOC203076 8p23.1 similar to 4930578I06Rik protein SOX7 8p22 SRY (sex determining region Y)-box 7 PINX1 8p23 SRY (sex determining region Y)-box 7 LOC389624 8 LOC389624 LOC286046 8p23.1 hypothetical protein LOC286046 C8orf5 8p22 chromosome 8 open reading frame 5 C8orf15 8p23.1 chromosome 8 open reading frame 15 C8orf6 8p23.1 chromosome 8 open reading frame 6 C8orf7 8p22 chromosome 8 open reading frame 7 LOC392193 8 similar to 60S ribosomal protein L19 LOC157740 8p23.1 hypothetical protein C8orf9 MTMR9 8p23-p22 myotubularin related protein 9 AMAC 8p22 acyl-malonyl condensing enzyme TDH 8p22 L-threonine dehydrogenase C8orf12 8p22 chromosome 8 open reading frame 12 C8orf13 8p22 chromosome 8 open reading frame 13 BLK 8p23-p22 B lymphoid tyrosine kinase C8orf14 8p22 chromosome 8 open reading frame 14 GATA4 8p23.1 GATA binding protein 4 NEIL2 8p23.1 nei like 2 (E. coli) LOC389625 8 similar to Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (p14) FDFT1 8p23.1-p22 farnesyl-diphosphate farnesyltransferase 1 CTSB 8p22 cathepsin B LOC392194 8 similar to putative taste receptor HTR2 LOC389626 8 similar to seven transmembrane helix receptor LOC392195 8 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC344951 8p23.1 similar to seven transmembrane helix receptor LOC389627 8 similar to hypothetical protein LOC169270 LOC389628 8 hypothetical gene supported by AK096301 LOC392196 8 similar to ubiquitin-specific protease 17-like protein LOC392197 8 similar to ubiquitin-specific protease 17-like protein LOC392198 8 similar to ubiquitin-specific protease 17-like protein LOC389629 8 LOC389629 LOC389630 8 similar to FLJ10408 protein LOC392199 8 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7421 - 549 - 2008 11275328
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Hearing/Equilibriumear   highly
Nervousbrain    
Reproductivefemale systemovary  highly
 male systemtestis   
 male systemprostate   
Respiratorylung    
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • double-helical motif similar to the SET interaction domain
  • a myotubularin-related domain
  • HOMOLOGY
    Homologene
    FAMILY
  • non-receptor class of the protein-tyrosine phosphatase family, myotubularin protein family
  • inositol polyphosphate 3-phosphatases family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text as MTMR6, accumulate in the perinuclear region, although MTMR6 shows less punctate distribution in the cytosolic compartment when compared with MTMR9
    basic FUNCTION
  • could act in the hypothalamic region together with MTMR7
  • may play some roles in regulation of appetite-related neuropeptides through insulin signaling in hypothalamus
  • may have have a role in the control of cell proliferation
  • could be involved in appetite regulation
  • potentiate the effects of MTMR6 on apoptosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phosphoinositide metabolism
    a component
  • MTMR6/MTMR9 complex serves to inhibit stress-induced apoptosis and the MTMR8/MTMR9 complex inhibits autophagy
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with active phosphatases MTMR7 and MTMR6 and regulates MTMR7 phosphatase activity
  • interaction of MTMR8 with MTMR9
  • MTMR6-MTMR9 interaction is critical for lipid binding, catalytic activity, and protein stability of MTMR6
  • MTMR6 interacts with MTMR9 and that MTMR9 is the major binding protein of MTMR6
  • cell & other
    REGULATION
    inhibited by high-fat diet
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity
  • to metabolic syndrome
  • to prediabetes
  • Variant & Polymorphism SNP , other
  • increasing the risk of obesity
  • variations influence the risk of metabolic syndrome
  • MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS