Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MTMR9 contributors: mct/pgu - updated : 01-06-2017
HGNC name myotubularin related protein 9
HGNC id 14596
DNA
TYPE functioning gene
STRUCTURE 43.65 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure 10 cm distal to MTMR7
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7421 - 549 - 2008 11275328
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Hearing/Equilibriumear   highly
Nervousbrain    
Reproductivefemale systemovary  highly
 male systemtestis   
 male systemprostate   
Respiratorylung    
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • double-helical motif similar to the SET interaction domain
  • a myotubularin-related domain
  • HOMOLOGY
    Homologene
    FAMILY
  • non-receptor class of the protein-tyrosine phosphatase family, myotubularin protein family
  • inositol polyphosphate 3-phosphatases family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text as MTMR6, accumulate in the perinuclear region, although MTMR6 shows less punctate distribution in the cytosolic compartment when compared with MTMR9
    basic FUNCTION
  • could act in the hypothalamic region together with MTMR7
  • may play some roles in regulation of appetite-related neuropeptides through insulin signaling in hypothalamus
  • may have have a role in the control of cell proliferation
  • could be involved in appetite regulation
  • potentiate the effects of MTMR6 on apoptosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phosphoinositide metabolism
    a component
  • MTMR6/MTMR9 complex serves to inhibit stress-induced apoptosis and the MTMR8/MTMR9 complex inhibits autophagy
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with active phosphatases MTMR7 and MTMR6 and regulates MTMR7 phosphatase activity
  • interaction of MTMR8 with MTMR9
  • MTMR6-MTMR9 interaction is critical for lipid binding, catalytic activity, and protein stability of MTMR6
  • MTMR6 interacts with MTMR9 and that MTMR9 is the major binding protein of MTMR6
  • cell & other
    REGULATION
    inhibited by high-fat diet
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity
  • to metabolic syndrome
  • to prediabetes
  • Variant & Polymorphism SNP , other
  • increasing the risk of obesity
  • variations influence the risk of metabolic syndrome
  • MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS