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FLASH GENE
Symbol MTMR3 contributors: npt/ - updated : 28-03-2006
HGNC name myotubularin related protein 3
HGNC id 7451
Location 22q12.2      Physical location : 30.279.157 - 30.426.855
Synonym name
  • cDNA sequence,expressed in brain,>100kDa,related to myotubularin MTM1
  • FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity
  • protein phosphatase
  • zinc finger, FYVE domain containing 10
  • Synonym symbol(s) KIAA0371, FYVE-DSP1, ZFYVE10, FLJ32333
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 147.70 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 8924 130.4 1170 - Zhao (2000)
    19 - 8897 129.3 1161 - Zhao (2000)
    20 - 9008 133.5 1198 - Zhao (2000)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • region similar to the active site of tyrosine phosphatases
  • a double-helical motif similar to the SET interaction domain
  • a FYVE domain at C-terminus
  • HOMOLOGY
    interspecies homolog to C.elegans y60a3a.16
    intraspecies homolog to myotubularin protein 3
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class myotubularin subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • protein tyrosine/serine/threonine phosphatase
  • putatively involved in signal transduction
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphatidylinositol (3)-phosphate
  • cell & other
    REGULATION
    inhibited by sodium vanadate and pervanadate,ph dependency
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS