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FLASH GENE
Symbol MTCH2 contributors: mct/shn/pgu - updated : 19-09-2015
HGNC name mitochondrial carrier homolog 2 (C. elegans)
HGNC id 17587
Location 11p11.2      Physical location : 47.638.858 - 47.664.206
Synonym name
  • Met-induced mitochondrial protein
  • mitochondrial carrier homolog 2
  • mitochondrial carrier 2
  • Synonym symbol(s) 2310034D24Rik, HSPC032, MIMP, SLC25A50
    DNA
    TYPE functioning gene
    STRUCTURE 25.35 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D11S1344 - D11S4109 - MTCH2 - D11S4117 - D11S1784 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2628 33 303 - 2005 15899861
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   moderately
    Reproductivefemale systemovary  moderately
     female systemuterus  lowly
     male system   highly
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite   Homo sapiens
    Muscularsmooth  lowly
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane domains
  • an energy transfer signature motif
  • HOMOLOGY
    interspecies ortholog to MTCH2, Pan troglodytes
    ortholog to Mtch2, Mus musculus
    ortholog to Mtch2, Rattus norvegicus
    ortholog to mtch2, Danio rerio
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text a surface-exposed outer mitochondrial membrane protein
    basic FUNCTION
  • mitochondrial target of truncated BID and this MTCH2-resident complex participates in the mitochondrial apoptotic program
  • mitochondrial carrier homologue upregulated by Met-hepatocyte growth factor (HGF) signal transduction, which leads to mitochondrial depolarization
  • a critical role in liver apoptosis by regulating the recruitment of tBID to mitochondria
  • has a major role in the mitochondrial outer membrane permeabilization by facilitating the recruitment of truncated BID protein to mitochondria
  • may play a role in cellular processes underlying obesity
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with truncated BID
  • interaction of MTCH2 and tBID is a potential target for therapeutic control of BID initiated cell death
  • binding of BID to MTCH2 suggesting both a quasi-constitutive residence of BID in MTCH2-bound state in healthy cells and its CASP8-mediated cleavage there under apoptotic conditions
  • role for MOAP1 in FAS signaling in the liver by promoting MTCH2-mediated BID recruitment to mitochondria
  • cell & other
    REGULATION
    induced by Met-hepatocytes growth factor/scatter factor (HGF/SF)
    Other up-regulated in NIH-3T3 cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
  • associated with body mass index
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of truncated BID protein to mitochondria, the activation of Bax/Bak, mitochondrial outer membrane permeabilization and apoptosis
  • MTCH2/MIMP conditional knockout in liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria