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FLASH GENE
Symbol MT-ND3 contributors: mct/ - updated : 31-08-2010
HGNC name mitochondrially encoded NADH dehydrogenase 3
HGNC id 7458
Corresponding disease
MTENC2 mitochondrial encephalopathy type Leigh syndrome, 2
Location mt      Physical location : -
Synonym name
  • NADH-ubiquinone oxidoreductase chain 3
  • NADH dehydrogenase subunit 3
    • Synonym symbol(s) MTND3, ND3, NAD3
    EC.number 1.6.5.3
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 346 13 15 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Mtnd3
    homolog to C.elegans VB0393
    Homologene
    FAMILY
  • complex I subunit 3 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalyzing restriction of ubiquinone or ubiquinol by NADH in the respiratory chain
  • structural component involved in the active/deactive enzyme transition of respiratory complex I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the fourty one subunits of complex I, in the hydrophobic protein fragment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTENC2
    Susceptibility parkinson disease
    Variant & Polymorphism 10398A>G associated with reduced risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS