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FLASH GENE
Symbol MT-ND3 contributors: mct/ - updated : 31-08-2010
HGNC name mitochondrially encoded NADH dehydrogenase 3
HGNC id 7458
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 346 13 15 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
mono polymer heteromer , complex
HOMOLOGY
interspecies ortholog to murine Mtnd3
homolog to C.elegans VB0393
Homologene
FAMILY
  • complex I subunit 3 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • catalyzing restriction of ubiquinone or ubiquinol by NADH in the respiratory chain
  • structural component involved in the active/deactive enzyme transition of respiratory complex I
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
  • one of the fourty one subunits of complex I, in the hydrophobic protein fragment
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTENC2
    Susceptibility parkinson disease
    Variant & Polymorphism 10398A>G associated with reduced risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS