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FLASH GENE
Symbol MST1 contributors: mct/npt/pgu - updated : 21-04-2009
HGNC name macrophage stimulating 1 (hepatocyte growth factor-like)
HGNC id 7380
Corresponding disease
MST1D MST1 deficiency
Location 3p21.31      Physical location : 49.721.380 - 49.726.196
Synonym name
  • scatter factor
  • hepatocyte growth factor-like protein homolog
  • hepatocyte growth factor-like protein alpha chain
  • hepatocyte growth factor-like protein beta chain
  • Synonym symbol(s) HGFL, MSP, D3F15S2, DNF15S2, NF15S2, hippo
    DNA
    TYPE functioning gene
    STRUCTURE 3.98 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure mutant TP53 associates with the promoter and represses its transcriptional activity, leading to a decrease in mRNA levels and a subsequent decrease in the levels of secreted protein
    MAPPING cloned Y linked N status confirmed
    Map MST1 - APEH
    Physical map
    WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene) GPX1 3p21.2 glutathione peroxidase 1 ARHA 3p21.2 ras homolog gene family, member A TCTA 3p21 T-cell leukemia translocation altered gene AMT 3p21.2 aminomethyltransferase (glycine cleavage system protein T) NICN1 3p21.31 nicolin 1 DAG1 3p21.2-p21.1 dystroglycan 1 (dystrophin-associated glycoprotein 1) BSN 3p21.31 bassoon (presynaptic cytomatrix protein) APEH 3p21.3-p21.2 N-acylaminoacyl-peptide hydrolase MST1 3p21.31 macrophage stimulating 1 (hepatocyte growth factor-like) RNF123 3p24.3 ring finger protein 123 GMPPB 3p21.31 GDP-mannose pyrophosphorylase B IHPK1 3p21.31 inositol hexaphosphate kinase 1 LOC389117 3 similar to mouse fat 1 cadherin LOC389118 3 similar to VLLR9392 LOC389119 3 similar to RIKEN cDNA 6530418L21 UBE1L 3p21.2 ubiquitin-activating enzyme E1-like TRIP 3p21.31 TRAF interacting protein MGC8407 3p21.31 hypothetical protein MGC8407 LOC389120 3 similar to RIKEN cDNA 4921517D21 LOC285405 3p21.31 similar to RIKEN cDNA 4921517D21 MST1R 3p21.3 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) MGC13272 3p21.31 hypothetical protein MGC13272 RBM6 3p21.3 RNA binding motif protein 6 RBM5 3p21.3 RNA binding motif protein 5 SEMA3F 3p21.31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F GNAT1 3p21.2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2348 82 725 - 2008 18480548
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal kinase domain
  • four cysteine-rich kringle domains
  • heterodimeric transmembrane glycoprotein (beta=150kD, alpha=35kD)
  • two carboxy-terminal nuclear export signals (NES)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to hippo
    intraspecies paralog to HGF
    Homologene
    FAMILY
  • peptidase S1 family
  • plasminogen subfamily
  • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating macrophage migration, phagocytosis, and nitric oxide production
  • involved in the regulation of peripheral macrophage activation
  • has the potential to modulate inflammatory actions of microglia, which proposes novel aspects for the process of degeneration and/or regeneration of the brain
  • protein regulating the innate immune responses to bacterial ligands and may have a role in the pathogenesis of inflammatory bowel diseases
  • stimulates transcription of the proapoptotic mediator PMAIP1 in a FOXO1-dependent manner
  • MST1/MST1R signaling seems to play at least some role in the pathogenesis of Merkel cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • Hippo/MST1-FOXO1-PMAIP1 pathway
  • a component
  • MST1/MST1R system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MST1R ligand
  • interacting with RCC1 (RCC1 immobilization on the chromosomes at early stages of apoptosis is dependent on MST1 and its phosphorylation of histone H2B)
  • major determinant of RASSF2 protein stability
  • interacts strongly with RASSF5 but only weakly other components of the mammalian Hippo signaling pathway
  • SAFB bound to AR and phosphorylated by MST1, previously shown to be an AR repressor, and MST1 localization to AR-dependent promoters was inhibited by SAFB depletion
  • cell & other
    REGULATION
    Other MST1 kinase activity is regulated by RASSF2 via RASSF2-MST1 protein complex formation
    ASSOCIATED DISORDERS
    corresponding disease(s) MST1D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    reduced expression was observed in many types of cancer, including large-cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS