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FLASH GENE
Symbol MSH4 contributors: - updated : 27-02-2007
HGNC name mutS homolog 4 (E. coli)
HGNC id 7327
Location 1p31      Physical location : 76.262.629 - 76.378.923
Synonym symbol(s) RP11-262K24.2
DNA
TYPE functioning gene
STRUCTURE 116.00 kb     20 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 mouth    
Reproductivemale systemtestis  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , polymer
HOMOLOGY
interspecies homolog to yeast meiosis-specific protein
homolog to bacterial mutS,4
homolog to murine Mhs4
homolog to C.elegans ZK1127.11
Homologene
FAMILY DNA mismatch repair MUTS family
CATEGORY regulatory , DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • involved in meiotic recombination required for reciprocal recombination
  • play an important role in the meiotic processes
  • may be involved in diverse cellular processes through interaction with different protein partners, and the levels of VHL protein expression in cells could potentially affect the availability of the hMSH4-hMSH5 hetero-complex
  • role for MSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, recombination
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MSH4/MSH6 heterooligomer
    INTERACTION
    DNA
    RNA MLH3 in meiotic cells
    small molecule
    protein
  • MSH5
  • interacting with VHL
  • EIF3F is a MSH4 interacting protein (EIF3F functions not only in translation but also in the regulation of apoptosis and tumorigenesis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS