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FLASH GENE
Symbol MSH4 contributors: mct - updated : 13-10-2020
HGNC name mutS homolog 4 (E. coli)
HGNC id 7327
DNA
TYPE functioning gene
STRUCTURE 116.36 kb     20 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3270 - 936 - 2013 24145748
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 mouth    
Reproductivemale systemtestis  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , polymer
HOMOLOGY
interspecies homolog to yeast meiosis-specific protein
homolog to bacterial mutS,4
homolog to murine Mhs4
homolog to C.elegans ZK1127.11
Homologene
FAMILY DNA mismatch repair MUTS family
CATEGORY regulatory , DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • involved in meiotic recombination required for reciprocal recombination
  • play an important role in the meiotic processes
  • may be involved in diverse cellular processes through interaction with different protein partners, and the levels of VHL protein expression in cells could potentially affect the availability of the hMSH4-hMSH5 hetero-complex
  • role for MSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair
  • CELLULAR PROCESS cell cycle,division,meiosis
    nucleotide, recombination
    nucleotide, repair, mismatch repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MSH4/MSH6 heterooligomer
    INTERACTION
    DNA
    RNA MLH3 in meiotic cells
    small molecule
    protein
  • MSH5
  • interacting with VHL
  • EIF3F is a MSH4 interacting protein (EIF3F functions not only in translation but also in the regulation of apoptosis and tumorigenesis)
  • interplay between MSH4 and KAT8 manipulates the outcomes of nonhomologous end joining (NHEJ)-mediated DNA double strand break (DSB) repair and thereby controls cell survival in response to ionizing radiation (IR)
  • MSH4 interacts with HDAC3, and HDAC3 negatively regulates the levels of MSH4 acetylation
  • SHOC1 forms discrete foci on chromosomes axes, and is required for the localization of TEX11 and another ZMM protein, MSH4, to form crossover-prone recombination intermediates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in three patients with gliomas
    constitutional germinal mutation      
    in premature ovarian insufficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS