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FLASH GENE
Symbol MSH3 contributors: mct - updated : 14-09-2016
HGNC name mutS homolog 3 (E. coli)
HGNC id 7326
Corresponding disease
FAP4 familial adenomatous polyposis 4
Location 5q14.1      Physical location : 79.950.293 - 80.172.633
Synonym name
  • divergent upstream protein
  • mismatch repair protein 1
  • DNA mismatch repair protein Msh3
  • Synonym symbol(s) DUG, DUC1, DUP, MRP1, MGC163308
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text divergently transcribed upstream gene,overlapping and transcribed in opposite orientation (see TSG5B) of dehydrofolate reductase
    STRUCTURE 222.34 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ARSB 5q13 arylsulfatase B DMGDH 5q12.2-q12.3 arylsulfatase B BHMT2 5q13 betaine-homocysteine methyltransferase 2 BHMT 5q13.1-q15 betaine-homocysteine methyltransferase JMY 5q14.1 junction-mediating and regulatory protein HOMER1 5q25 homer homolog 1 (Drosophila) LOC133748 5q14.1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) FLJ38499 5q14.1 hypothetical protein FLJ38499 CMYA5 5q14.1 cardiomyopathy associated 5 LOC391802 5 similar to 60S ribosomal protein L10 (QM protein homolog) LOC345778 5q14.1 similar to hypothetical protein THBS4 5q13 thrombospondin 4 C5orf12 5 chromosome 5 open reading frame 12 LOC391803 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC134478 5q14.1 similar to cytoplasmic beta-actin NYD-TSP1 5q14.1 testis-specific protein NYD-TSP1 LOC391804 5 similar to hypothetical protein LOC391805 5 hypothetical gene supported by NM_004269 LOC153817 5q14.1 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) ZFYVE16 5p15.2-q14.3 zinc finger, FYVE domain containing 16 LOC167555 5q14.1 similar to AASA9217 LOC340120 5q14.1 similar to RIKEN cDNA 6430502M16 gene LOC389306 5 LOC389306 DBIL1 5pter-p15.32 diazepam binding inhibitor-like 1 DHFR 5q13.2 dihydrofolate reductase MSH3 5q11-q12 mutS homolog 3 (E. coli) RASGRF2 5q13 Ras protein-specific guanine nucleotide-releasing factor 2 CKMT2 5q13.3 creatine kinase, mitochondrial 2 (sarcomeric) DKFZp761J139 5q14.1 hypothetical protein DKFZp761J139 CACH-1 5q14.1 cytosolic acetyl-CoA hydrolase SSBP2 5q14.1 single-stranded DNA binding protein 2 DSS1P1 5q14 single-stranded DNA binding protein 2 APG10L 5q14.1 APG10 autophagy 10-like (S. cerevisiae) PPIP1 5q14.1 peptidylprolyl isomerase (cyclophilin) pseudogene 1 RPS23 5q13-q14 ribosomal protein S23 LOC92270 5q14.1 hypothetical protein LOC92270
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 polyA site 4645 - 1137 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier/lining   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a region of homology with other Muts or MutL homologs, comprising a region of 150 aminoacids encompassing a putative helix-turn-helix domain associated with an adenine nucleotide and magnesium binding site
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast mutator gene
    homolog to C.elegans C14C10.4
    Homologene
    FAMILY
  • DNA mismatch repair mutS family
  • MSH3 subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • protein possessing an intrinsic low-level ATPase activity
  • MSH2/MSH3, discriminates between a repair-competent and a repair-resistant loop by sensing the conformational dynamics of their junctions
  • MSH2-MSH3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions
  • MSH2-MSH3 is required for 3prime non-homologous tail removal in double-strand break repair and, MSH2-MSH3 binds double-strand/single-strand junctions and initiates repair in an ATP-dependent manner
  • MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in TP53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as well
  • MSH2-MSH3 plays an important role in shifting the expansion-contraction equilibrium toward expansion in the early stages of Trinucleotide repeat (TNR) tract expansion
  • CELLULAR PROCESS nucleotide, repair, mismatch repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with MSH2 in mismatch repair
  • MSH2-MSH3 heterodimer recognizes various DNA mispairs, including loops of DNA ranging from 1 to 14 nucleotides and some base-base mispairs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSH6 to tumor supression
  • MLH1
  • MLH1-MLH3, a meiotic crossover and DNA mismatch repair factor, is a MSH2-MSH3-stimulated endonuclease
  • MSH2 interacts with MSH6 or MSH3 to form the MutSalpha or MutSbeta complex, respectively, which recognize base-base mispairs and insertions/deletions and initiate the repair process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FAP4
    Susceptibility to prostate cancer
    Variant & Polymorphism other
  • association of MSH3 gene polymorphisms in prostate cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Msh3 knock out mouse