Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MSH3 contributors: mct - updated : 14-09-2016
HGNC name mutS homolog 3 (E. coli)
HGNC id 7326
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region of homology with other Muts or MutL homologs, comprising a region of 150 aminoacids encompassing a putative helix-turn-helix domain associated with an adenine nucleotide and magnesium binding site
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast mutator gene
    homolog to C.elegans C14C10.4
    Homologene
    FAMILY
  • DNA mismatch repair mutS family
  • MSH3 subfamily
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • protein possessing an intrinsic low-level ATPase activity
  • MSH2/MSH3, discriminates between a repair-competent and a repair-resistant loop by sensing the conformational dynamics of their junctions
  • MSH2-MSH3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions
  • MSH2-MSH3 is required for 3prime non-homologous tail removal in double-strand break repair and, MSH2-MSH3 binds double-strand/single-strand junctions and initiates repair in an ATP-dependent manner
  • MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in TP53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as well
  • MSH2-MSH3 plays an important role in shifting the expansion-contraction equilibrium toward expansion in the early stages of Trinucleotide repeat (TNR) tract expansion
    • CELLULAR PROCESS nucleotide, repair, mismatch repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with MSH2 in mismatch repair
  • MSH2-MSH3 heterodimer recognizes various DNA mispairs, including loops of DNA ranging from 1 to 14 nucleotides and some base-base mispairs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSH6 to tumor supression
  • MLH1
  • MLH1-MLH3, a meiotic crossover and DNA mismatch repair factor, is a MSH2-MSH3-stimulated endonuclease
  • MSH2 interacts with MSH6 or MSH3 to form the MutSalpha or MutSbeta complex, respectively, which recognize base-base mispairs and insertions/deletions and initiate the repair process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FAP4
    Susceptibility to prostate cancer
    Variant & Polymorphism other
  • association of MSH3 gene polymorphisms in prostate cancer
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Msh3 knock out mouse