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FLASH GENE

Symbol

MPC1

contributors: mct - updated : 10-04-2013

HGNC name	mitochondrial pyruvate carrier 1
HGNC id	21606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q27      Physical location : -
Synonym name	HSPC040 protein
	brain protein 44-like
Synonym symbol(s)	dJ68L15.3, CGI-129, PNAS-115, BRP44L, MPYCD

DNA

TYPE	functioning gene
STRUCTURE	18.09 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016098 5 - 977 NP_057182 - 109 - 2012 22628558 NM_001270879 6 - 1193 NP_001257808 - 66 - 2012 22628558

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Brp44l

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
text	MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane

basic FUNCTION	essential for mitochondrial pyruvate transport (
	MPC1 and MPC2 form an essential part of the mitochondrial pyruvate carrier
	MPC1 and MPC2 are obligatory components of facilitated pyruvate transport in mammalian cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS