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FLASH GENE
Symbol MPC1 contributors: mct - updated : 10-04-2013
HGNC name mitochondrial pyruvate carrier 1
HGNC id 21606
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 977 - 109 - 2012 22628558
6 - 1193 - 66 - 2012 22628558
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Brp44l
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
text
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
  • basic FUNCTION
  • essential for mitochondrial pyruvate transport (
  • MPC1 and MPC2 form an essential part of the mitochondrial pyruvate carrier
  • MPC1 and MPC2 are obligatory components of facilitated pyruvate transport in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS