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FLASH GENE
Symbol MOCOS contributors: mct - updated : 15-05-2013
HGNC name molybdenum cofactor sulfurase
HGNC id 18234
Corresponding disease
XDH2 xanthinuria type 2
Location 18q12.2      Physical location : 33.767.479 - 33.848.684
Synonym name MoCo sulfurase
Synonym symbol(s) FLJ20733, HMCS, MOS
EC.number 2.8.1.9 / 3.4.25.1
DNA
TYPE functioning gene
STRUCTURE 81.21 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC147354 18q12.1 similar to additional sex combs like 2; polycomb group protein ASXH2 KIAA1713 18q11 KIAA1713 protein NOL4 18q12 nucleolar protein 4 DTNA 18q12.1-q12.2 dystrobrevin, alpha LOC390849 18 similar to ribosomal protein L10a MAPRE2 18q12 microtubule-associated protein, RP/EB family, member 2 ZNF397 18q12.1 zinc finger protein 397 ZNF271 18q12 zinc finger protein 271 ZNF24 18q12 zinc finger protein 24 (KOX 17) ZNF396 18p12 zinc finger protein 396 LOC125476 18q12.2 hypothetical protein LOC125476 GALNT1 18q12.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) LOC388473 18 LOC388473 PNAS-131 18q12.2 hypothetical protein PNAS-131 P15RS 18q12.2 hypothetical protein FLJ10656 SLC39A6 18q12.2 solute carrier family 39 (zinc transporter), member 6 STATIP1 18q12.1 signal transducer and activator of transcription 3 interacting protein 1 MOCOS 18q12 molybdenum cofactor sulfurase RNU4P3 18q12.2 RNA, U4 small nuclear pseudogene 3 LOC390850 18 similar to RIKEN cDNA 0610008N23 KIAA1695 DKFZP586M1523 KIAA1328 18q12.2 KIAA1328 protein BRUNOL4 18q12 bruno-like 4, RNA binding protein (Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2747 - 888 - 2007 17368066
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 salivary gland   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal NIFS like domain with pyridoxal phosphate (PLP) dependent cysteine desulfurase activity
  • seven C2H2 type zinc finger domain
  • a C-terminal domain with a hypothetical function of transferring the sulfur extracted by the NIFS like domain to the molybdenum cofactor
  • HOMOLOGY
    interspecies homolog to C.elegans F49E2.1
    homolog to Drosophila Ma1
    Homologene
    FAMILY
  • class-V pyridoxal-phosphate-dependent aminotransferase family
  • MOCOS subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the removal of elemental sulfur from cysteine to produce alanine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) XDH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS