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FLASH GENE
Symbol MOCOS contributors: mct - updated : 15-05-2013
HGNC name molybdenum cofactor sulfurase
HGNC id 18234
DNA
TYPE functioning gene
STRUCTURE 81.21 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2747 - 888 - 2007 17368066
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 salivary gland   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal NIFS like domain with pyridoxal phosphate (PLP) dependent cysteine desulfurase activity
  • seven C2H2 type zinc finger domain
  • a C-terminal domain with a hypothetical function of transferring the sulfur extracted by the NIFS like domain to the molybdenum cofactor
  • HOMOLOGY
    interspecies homolog to C.elegans F49E2.1
    homolog to Drosophila Ma1
    Homologene
    FAMILY
  • class-V pyridoxal-phosphate-dependent aminotransferase family
  • MOCOS subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the removal of elemental sulfur from cysteine to produce alanine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) XDH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS