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FLASH GENE
Symbol MMP3 contributors: mct/pgu - updated : 08-02-2014
HGNC name matrix metalloproteinase 3 (stromelysin 1, progelatinase)
HGNC id 7173
Location 11q22.2      Physical location : 102.706.527 - 102.714.342
Synonym name
  • proteoglycanase
  • stromelysin 1
  • transin-1
  • Synonym symbol(s) STMY1, STR1, SL-1, MGC126103, MGC126104, MMP-3, CHDS6
    EC.number 3.4.24.17
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE component of a cluster
    text member of the MMP cluster
    STRUCTURE 7.82 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • promoter known to be transactivated by Ets proteins through palindromic head-to-head Ets binding sites (EBS), an unusual configuration among metalloproteinase promoters
  • MAPPING cloned Y linked Y status confirmed
    Map see DRD2
    Physical map
    MGC13040 11q22.2 hypothetical protein MGC13040 YAP1 11q13 Yes-associated protein 1, 65kDa LOC120318 11q22.2 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) BIRC3 11q25 baculoviral IAP repeat-containing 3 BIRC2 11q22 baculoviral IAP repeat-containing 2 PORIMIN 11q22.1 Homo sapiens pro-oncosis receptor inducing membrane injury gene (PORIMIN), mRNA. MMP7 11q22.2-q22.3 matrix metalloproteinase 7 (matrilysin, uterine) MMP20 11q22.2-q22.3 matrix metalloproteinase 20 (enamelysin) MMP27 11q24 matrix metalloproteinase 27 MMP8 11q22.2-q22.3 matrix metalloproteinase 8 (neutrophil collagenase) LOC390248 11 similar to matrix metalloproteinase 1 precursor MMP10 11q22.2-q22.3 matrix metalloproteinase 10 (stromelysin 2) MMP1 11q22.2-q22.3 matrix metalloproteinase 1 (interstitial collagenase) LOC120321 11q22.2 similar to casein kinase 1, alpha 1 MMP3 11q22.2-q22.3 matrix metalloproteinase 3 (stromelysin 1, progelatinase) MMP12 11q22.3 matrix metalloproteinase 12 (macrophage elastase) MMP13 11q22.2-q22.3 matrix metalloproteinase 13 (collagenase 3) MGC2714 11q22.2 hypothetical protein MGC2714 DNCH2 11q21-q22.1 dynein, cytoplasmic, heavy polypeptide 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1828 52.2 477 - 2008 18172013
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text developing bone
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • a prodomain with a cysteine residue, essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc-binding site
  • a hinge region
  • a hemopexin-like C terminal domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Mmp3
    Homologene
    FAMILY
  • peptidase family m10 A
  • matrixin subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text detected in the nuclei of normal and osteoarthritic chondrocytes
    basic FUNCTION
  • regulator of matrix remodeling
  • activates a number of pro-MMPs
  • critical role for the generation of the fully active MMP1
  • involved in cell migration, mammary epithelial cell apoptosis and alveolar formation, mammary epithelial-mesenchymal cell conversion, generation of angiostatin-like fragment
  • involved in enhanced collagen affinity, release of bFGF, increased bioavailability of IGF1, TGF beta and cell, pro/antiinflammatory roles
  • inhibiting breast tumor cell invasion by a mechanism involving plasminogen degradation to fragments that limit plasminogen activation and the degradation of laminin
  • involved in disrupted cell aggregation and increased cell invasion
  • signaling proteinase from apoptotic neuronal cells that activates microglia, and may play a major role in degenerative brain disorders, such as Parkinson's disease
  • having a function as a trans regulator of connective tissue growth factor (CTGF)
  • plays a role in the ER stress-induced apoptosis
  • is both a direct transcriptional target and a necessa
  • involvement in digestion of SNCA in dopaminergic neurons, playing a pivotal role in the progression of Parkinson disease through modulation of SNCA in aggregation, Lewy body formation, and neurotoxicity
  • may contribute to the breakdown of articular cartilage during arthritis
  • role in the pathogenesis of idiopathic pulmonary fibrosis, through activation of beta-catenin signaling and induction of epithelial-mesenchymal transition
  • GPR65 is vital regulatory genes upstream of MMP3
  • role for SDC4 in mediating matrix degradation in both intervertebral discs and cartilage by controlling ADAMTS5 function and MMP3 expression
  • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    cell migration & motility
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ZBP89
  • binding TIMPs in a 1:1 stoechiometry
  • cell & other
    REGULATION
    activated by proteinases and plasmin
    induced by by overexpression of a constitutively active form of NFATC3 in astrocytes
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer in advanced stage
    constitutional     --low  
    AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls
    Susceptibility
  • abdominal aortic aneurysm and carotid artery atherosclerosis
  • myocardial infarction
  • to Moyamoya disease (MMD)
  • Variant & Polymorphism other
  • polymorphism 5A/5A in non smocker and 6A/6A in smocker increasing the risk of acute myocardial infarction
  • the 5A allele frequency was higher in abdominal aortic aneurysm compared with controls
  • functional polymorphism in the promoter might be associated with susceptibility to MMD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    MMP3 may serve as cellular targets for therapy against neurodegenerative diseases
    ANIMAL & CELL MODELS