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FLASH GENE
Symbol MMP3 contributors: mct/pgu - updated : 08-02-2016
HGNC name matrix metalloproteinase 3 (stromelysin 1, progelatinase)
HGNC id 7173
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in breast cancer in advanced stage
constitutional     --low  
AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls
Susceptibility
  • abdominal aortic aneurysm and carotid artery atherosclerosis
  • myocardial infarction
  • to Moyamoya disease (MMD)
  • Variant & Polymorphism other
  • polymorphism 5A/5A in non smocker and 6A/6A in smocker increasing the risk of acute myocardial infarction
  • the 5A allele frequency was higher in abdominal aortic aneurysm compared with controls
  • functional polymorphism in the promoter might be associated with susceptibility to MMD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    MMP3 may serve as cellular targets for therapy against neurodegenerative diseases
    ANIMAL & CELL MODELS