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FLASH GENE

Symbol

MMP15

contributors: - updated : 20-07-2006

HGNC name	matrix metalloproteinase 15 (membrane-inserted)
HGNC id	7161

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q13-q21      Physical location : 58.059.281 - 58.080.802
Synonym name	membrane-type matrix metalloproteinase 2
Synonym symbol(s)	MT2-MMP ,MTMMP2, SMCP2
EC.number	3.4.24.-

DNA

TYPE	functioning gene
STRUCTURE	20.00 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly Endocrine thyroid       highly Reproductive male system testis     highly Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
	a catalytic domain with the zinc binding site (the cysteine switch)
	a hinge region
	a furin activation sequence
	one hemopexin-like domain
	a C terminal hydrophobic extension,representing a putative transmembrane segment (1TM)

conjugated

HemoP , MetalloP

HOMOLOGY

Homologene

FAMILY

MMP family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	endopeptidase degrading various components of the extracellular matrix
	activates pro-MMP2 (independently of TIMP2)
	a role in reduced cell adhesion and spreading

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

membrane constituent

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+
	calcium Ca2+

protein	binding TIMPs in a 1:1 stoechiometry
	MMP2

cell & other

REGULATION

activated by

furin (intracellularly) and proteinases

inhibited by

TIMPs and TFPI2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   with MMP2 in melanoma, invasive and metastatic

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS