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FLASH GENE
Symbol MMP15 contributors: - updated : 20-07-2006
HGNC name matrix metalloproteinase 15 (membrane-inserted)
HGNC id 7161
Location 16q13-q21      Physical location : 58.059.281 - 58.080.802
Synonym name
  • membrane-type matrix metalloproteinase 2
  • Synonym symbol(s) MT2-MMP ,MTMMP2, SMCP2
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    CPNE2 16q13 copine II NIP30 16q13 NEFA-interacting nuclear protein NIP30 KIAA1972 16q13 KIAA1972 protein TM4SF11 16q12-q13 transmembrane 4 superfamily member 11 (plasmolipin) BART1 CX3CL1 16q13 chemokine (C-X3-C motif) ligand 1 CCL22 16q13 chemokine (C-C motif) ligand 22 CCL17 16q13 chemokine (C-C motif) ligand 17 LOC57019 16q13-q21 hypothetical protein LOC57019 POLR2C 16q13-q21 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa DOK4 16q13 docking protein 4 MGC10992 16q13 hypothetical protein LOC92922 GPR114 16q13 G protein-coupled receptor 114 LOC255519 16q13 similar to high mobility group protein homolog HMG4 GPR56 16q13 G protein-coupled receptor 56 GPR97 16q13 G protein-coupled receptor 97 DKFZp434I099 16q13 hypothetical protein DKFZp434I099 KATNB1 16q13 katanin p80 (WD repeat containing) subunit B 1 KIFC3 16q13-q21 kinesin family member C3 LOC388282 16 hypothetical gene supported by AF452719; BC041062 CNGB1 16q13 cyclic nucleotide gated channel beta 1 TEPP 16q13 testis/prostate/placenta-expressed protein ZNF319 16q21 zinc finger protein 319 FLJ13154 16q13 hypothetical protein FLJ13154 MMP15 16q13-q21 matrix metalloproteinase 15 (membrane-inserted) GTL3 16q13 likely ortholog of mouse gene trap locus 3 CSNK2A2 16p13.3-p13.2 casein kinase 2, alpha prime polypeptide HSPC065 16q13 HSPC065 protein FLJ13912 16q13 hypothetical protein FLJ13912 NDRG4 16q21-q22.3 NDRG family member 4 FLJ21148 16q13 hypothetical protein FLJ21148 KIAA1007 16q21 hypothetical protein FLJ21148 FLJ10815 16q13 hypothetical protein FLJ10815 GOT2 16q21 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Endocrinethyroid   highly
    Reproductivemale systemtestis  highly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc binding site (the cysteine switch)
  • a hinge region
  • a furin activation sequence
  • one hemopexin-like domain
  • a C terminal hydrophobic extension,representing a putative transmembrane segment (1TM)
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • endopeptidase degrading various components of the extracellular matrix
  • activates pro-MMP2 (independently of TIMP2)
  • a role in reduced cell adhesion and spreading
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component membrane constituent
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • zinc Zn2+
  • calcium Ca2+
  • protein
  • binding TIMPs in a 1:1 stoechiometry
  • MMP2
  • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with MMP2 in melanoma, invasive and metastatic
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS