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FLASH GENE
Symbol MMP15 contributors: - updated : 20-07-2006
HGNC name matrix metalloproteinase 15 (membrane-inserted)
HGNC id 7161
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
  • a catalytic domain with the zinc binding site (the cysteine switch)
  • a hinge region
  • a furin activation sequence
  • one hemopexin-like domain
  • a C terminal hydrophobic extension,representing a putative transmembrane segment (1TM)
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • endopeptidase degrading various components of the extracellular matrix
  • activates pro-MMP2 (independently of TIMP2)
  • a role in reduced cell adhesion and spreading
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component membrane constituent
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • zinc Zn2+
  • calcium Ca2+
  • protein
  • binding TIMPs in a 1:1 stoechiometry
  • MMP2
  • cell & other
    REGULATION
    activated by furin (intracellularly) and proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with MMP2 in melanoma, invasive and metastatic
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS