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FLASH GENE
Symbol MMP11 contributors: - updated : 04-05-2004
HGNC name matrix metalloproteinase 11 (stromelysin 3)
HGNC id 7157
Location 22q11.22      Physical location : 24.115.035 - 24.126.502
Synonym symbol(s) STMY3 ,ST3, SL-3,
EC.number 3.4.24.-
DNA
TYPE functioning gene
SPECIAL FEATURE
text member of the MMP cluster
STRUCTURE 11.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines tumors endothelial cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine residue essential for latency and involved in autocatalytic activation,
  • a catalytic domain with the zinc-binding site (the cysteine switch)
  • a furin activation sequence,
  • a hinge region and a hemopexin-like C terminal domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text extracellular matrix
    basic FUNCTION
  • regulator in matrix remodeling
  • playing an important role in the invasiveness of meningiomas
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by proteinases, others MMPs
    furin intracellularly
    inhibited by TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS