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FLASH GENE
Symbol MMP11 contributors: - updated : 04-05-2004
HGNC name matrix metalloproteinase 11 (stromelysin 3)
HGNC id 7157
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine residue essential for latency and involved in autocatalytic activation,
  • a catalytic domain with the zinc-binding site (the cysteine switch)
  • a furin activation sequence,
  • a hinge region and a hemopexin-like C terminal domain
    • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY MMP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text extracellular matrix
    basic FUNCTION
  • regulator in matrix remodeling
  • playing an important role in the invasiveness of meningiomas
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by proteinases, others MMPs
    furin intracellularly
    inhibited by TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS