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FLASH GENE
Symbol MME contributors: npt/ - updated : 09-09-2006
HGNC name membrane metallo-endopeptidase
HGNC id 7154
Location 3q25.2      Physical location : 154.797.435 - 154.901.518
Synonym name
  • antigen CD10 (gp100), 100kD identified by antibodies J5, VIL-A1, ALB2, neprilysin
  • neprilysin
  • common acute lymphoblastic leukemia antigen
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
  • enkephalinase
  • atriopeptidase
  • CD10 antigen
  • neutral endopeptidase 24.11
    • Synonym symbol(s) CALLA, CD10, NEP, MGC126681, MGC126707, DKFZp686O16152, EPN
    EC.number 3.4.24.11
    DNA
    TYPE functioning gene
    STRUCTURE 103.57 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    GPR105 3q21-q25 G protein-coupled receptor 105 GPR87 3q24 G protein-coupled receptor 87 GPR86 3q24 G protein-coupled receptor 86 P2RY12 3q24-q25 purinergic receptor P2Y, G-protein coupled, 12 FLJ25972 3q25.1 hypothetical protein FLJ25972 LOC344752 3q25.1 similar to Arylacetamide deacetylase LOC201651 3q25.1 similar to esterase/N-deacetylase (EC 3.5.1.-), 50K hepatic - rabbit AADAC 3q21.3-q25.2 arylacetamide deacetylase (esterase) GPR91 3q24-3q25.1 G protein-coupled receptor 91 MBNL1 3q25.1-q25.2 muscleblind-like (Drosophila) P2RY1 3q25 purinergic receptor P2Y, G-protein coupled, 1 RAP2B 3q25.2 RAP2B, member of RAS oncogene family LOC152118 3q25.2 hypothetical gene supported by AF086445 DKFZP434D146 3q25.2 DKFZP434D146 protein RH_II/GuBp2 3q25.2 similar to orphan seven transmembrane receptor DHX36 3q25 DEAH (Asp-Glu-Ala-His) box polypeptide 36 GPR149 3q25.2 G protein-coupled receptor 149 MME 3q25.1-q25.2 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) LOC256283 3q25.2 hypothetical LOC256283 KIAA1069 3q26.1 hypothetical LOC256283 FLJ31139 3q25.31 hypothetical protein FLJ31139 SLC33A1 3q25.31 solute carrier family 33 (acetyl-CoA transporter), member 1 GMPS 3q24 guanine monphosphate synthetase LOC389168 3 similar to template acyivating factor-I alpha LOC344760 3q25.31 similar to seven transmembrane helix receptor MRE11B 3q25 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) KCNAB1 3q26.1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 SSR3 3q25.31 signal sequence receptor, gamma (translocon-associated protein gamma) TIPARP 3q25.31 TCDD-inducible poly(ADP-ribose) polymerase LOC389169 3 hypothetical gene supported by BC001951; NM_006191 LOC389170 3 similar to hypothetical protein FLJ14957 LOC339892 3q25.31 similar to Death domain containing protein CRADD (Caspase and RIP adaptator with death domain) (RIP associated protein with a death domain) CCNL1 3q26.1 cyclin L1 LOC391589 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FLJ12604 3q24-q25 hypothetical protein FLJ12604 PTX3 3q21-q25 pentaxin-related gene, rapidly induced by IL-1 beta LOC152078 3q25.32 hypothetical protein BC010062 SHOX2 3q25-q26.1 short stature homeobox 2 MGC12197 3q25.32 BM-011 protein MLF1 3q25.1 myeloid leukemia factor 1 EFG1 3q25.1-q26.2 myeloid leukemia factor 1 LXN 3q25-q31 myeloid leukemia factor 1 RARRES1 3q25.31 retinoic acid receptor responder (tazarotene induced) 1 FLJ14153 3q25.32 hypothetical protein FLJ14153 GPR79 3q26 G protein-coupled receptor 79 pseudogene
    RNA
    TRANSCRIPTS type messenger
    text all transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5643 - 750 - -
    also called variant 1
    23 - 5619 - 750 - -
    also called variant 1bis
    23 - 5710 - 750 - -
    also called variant 2b
    23 - 5665 - 750 - -
    also called variant 2A
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemprostate   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single 24-amino acid hydrophobic segment that could function as both a transmembrane region and a signal peptide
  • a conserved pentapeptide zinc binding motif (HEXXH)
  • a second zinc binding motif and 10 cysteine residues
  • C-terminal 700 amino acids, including six potential N-linked glycosylation sites composing the extracellular protein segment
    • conjugated GlycoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase M13 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text transmembrane glycoprotein type II
    basic FUNCTION
  • playing a role in regulating cerebral amyloid deposition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of transmembrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by PROL1
    Other developmentally regulated in other cell types, i.e. lymphocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute lymphoblastic leukemias
    constitutional germinal mutation      
    truncating mutations causing alloimmunisation during pregnancy and diopathic renal failure in early adulthood (might be caused by immune-mediated fetal nephron loss)
    Susceptibility to late-onset Alzheimer's disease
    Variant & Polymorphism
    Candidate gene for the development of alternative therapies for Alzheimer's disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS