| 1 | CMT2T, MME, SCAR43
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| Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.
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| Auer-Grumbach M, Toegel S, Schabhüttl M, Weinmann D, Chiari C, Bennett DL, Beetz C, Klein D, Andersen PM, Böhme I, Fink-Puches R, Gonzalez M, Harms MB, Motley W, Reilly MM, Renner W, Rudnik-Schöneborn S, Schlotter-Weigel B, Themistocleous AC, Weishaupt JH, Ludolph AC, Wieland T, Tao F, Abreu L, Windhager R, Zitzelsberger M, Strom TM, Walther T, Scherer SS, Züchner S, Martini R, Senderek J.
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| Am J Hum Genet 99(3):607-23. doi: 10.1016/j.ajhg.2016.07.008.
2016
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| 2 | CMT2T, MME
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| Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2.
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| Higuchi Y, Hashiguchi A, Yuan J, Yoshimura A, Mitsui J, Ishiura H, Tanaka M, Ishihara S, Tanabe H, Nozuma S, Okamoto Y, Matsuura E, Ohkubo R, Inamizu S, Shiraishi W, Yamasaki R, Ohyagi Y, Kira J, Oya Y, Yabe H, Nishikawa N, Tobisawa S, Matsuda N, Masuda M, Kugimoto C, Fukushima K, Yano S, Yoshimura J, Doi K, Nakagawa M, Morishita S, Tsuji S, Takashima H.
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| Ann Neurol 79(4):659-72. doi: 10.1002/ana.24612. Epub 2016 Mar 17.
2016
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| 3 | MME, SCA43
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| MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43).
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| Depondt C, Donatello S, Rai M, Wang FC, Manto M, Simonis N, Pandolfo M.
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| Neurol Genet 2(5):e94. doi: 10.1212/NXG.0000000000000094. eCollection 2016 Oct.
2016
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| 4 | MME
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| Tumoral CD10 expression correlates with aggressive histology and prognosis in patients with malignant pleural mesothelioma.
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| Kadota K, Villena-Vargas J, Nitadori J, Sima CS, Jones DR, Travis WD, Adusumilli PS.
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| Ann Surg Oncol 22(9):3136-43. doi: 10.1245/s10434-015-4374-x. Epub 2015 Jan 22.
2015
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| 5 | HIF1A, MME
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| Hypoxia-inducible factor-1α mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells.
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| Wang H, Sun M, Yang H, Tian X, Tong Y, Zhou T, Zhang T, Fu Y, Guo X, Fan D, Yu A, Fan M, Wu X, Xiao W, Chui D.
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| J Neurochem 131(1):4-11. doi: 10.1111/jnc.12795. Epub 2014 Jul 28.
2014
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| 6 | MME, PRKCE
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| PKCε promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Aβ degradation in brain neurons.
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| Lim CS, Alkon DL.
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| PLoS One 9(5):e97756. doi: 10.1371/journal.pone.0097756. eCollection 2014.
2014
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| 7 | MME
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| A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.
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| Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E.
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| J Biol Chem 289(25):17917-31. doi: 10.1074/jbc.M114.557439. Epub 2014 May 13.
2014
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| 8 | MME, NPPC, NPR2
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| Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells--its relevance for CNP degradation.
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| Thong A, Müller D, Feuerstacke C, Mietens A, Stammler A, Middendorff R.
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| Mol Cell Endocrinol 382(1):234-43. doi: 10.1016/j.mce.2013.09.027. Epub 2013 Oct 4.
2014
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| 9 | CD44, MME
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| Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion.
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| Iwase A, Kotani T, Goto M, Kobayashi H, Takikawa S, Nakahara T, Nakamura T, Kondo M, Bayasula, Nagatomo Y, Kikkawa F.
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| Reprod Sci 21(1):82-8. doi: 10.1177/1933719113488449. Epub 2013 May 7.
2014
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| 10 | MME
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| The role of neprilysin in regulating the hair cycle.
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| Morisaki N, Ohuchi A, Moriwaki S.
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| PLoS One 8(2):e55947. doi: 10.1371/journal.pone.0055947. Epub 2013 Feb 13.
2013
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| 11 | MME
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| Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx.
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| Zraika S, Koh DS, Barrow BM, Lu B, Kahn SE, Andrikopoulos S.
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| Diabetes 62(5):1593-601. doi: 10.2337/db11-1593. Epub 2013 Jan 17.
2013
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| 12 | MME
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| Negative regulation of NEP expression by hypoxia.
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| Mitra R, Chao OS, Nanus DM, Goodman OB Jr.
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| Prostate 73(7):706-14. doi: 10.1002/pros.22613. Epub 2012 Nov 8.
2013
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| 13 | IAPP, MME
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| Degradation of islet amyloid polypeptide by neprilysin.
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| Guan H, Chow KM, Shah R, Rhodes CJ, Hersh LB.
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| Diabetologia 55(11):2989-98. doi: 10.1007/s00125-012-2678-y. Epub 2012 Aug 17.
2012
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| 14 | MME
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| CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis.
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| Faa G, Gerosa C, Fanni D, Nemolato S, Marinelli V, Locci A, Senes G, Mais V, Van Eyken P, Iacovidou N, Monga G, Fanos V.
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| J Matern Fetal Neonatal Med 25(7):904-11. doi: 10.3109/14767058.2011.599457. Epub 2012 Jan 25. 2012
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| 15 | MME
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| Localization of mature neprilysin in lipid rafts.
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| Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S.
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| J Neurosci Res 90(4):870-7. doi: 10.1002/jnr.22796. Epub 2011 Dec 20.
2012
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| 16 | MME
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| The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells.
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| Hong Y, Beckett C, Belyaev ND, Turner AJ.
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| Int J Cancer 130(4):775-86. doi: 10.1002/ijc.26028. Epub 2011 Jun 18.
2012
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| 17 | MME, TAC1
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| CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P.
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| Xie L, Takahara M, Nakahara T, Oba J, Uchi H, Takeuchi S, Moroi Y, Furue M.
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| Arch Dermatol Res 303(1):49-55. doi: 10.1007/s00403-010-1093-9. Epub 2010 Nov 13.
2011
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| 18 | MME
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| Anti-CD10 (56C6) is expressed variably in adrenocortical tumors and cannot be used to discriminate clear cell renal cell carcinomas.
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| Mete O, Kapran Y, Güllüoğlu MG, Kiliçaslan I, Erbil Y, Senyürek YG, Dizdaroğlu F.
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| Virchows Arch 456(5):515-21. 2010
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| 19 | MME
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| Circulating neprilysin clears brain amyloid.
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| Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB.
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| Mol Cell Neurosci 45(2):101-7. doi: 10.1016/j.mcn.2010.05.014. Epub 2010 Jun 15.
2010
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| 20 | MME
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| The CD10 enzyme is a key player to identify and regulate human mammary stem cells.
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| Bachelard-Cascales E, Chapellier M, Delay E, Pochon G, Voeltzel T, Puisieux A, Caron de Fromentel C, Maguer-Satta V.
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| Stem Cells 28(6):1081-8. doi: 10.1002/stem.435.
2010
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| 21 | MME
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| Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin.
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| Liang K, Yang L, Yin C, Xiao Z, Zhang J, Liu Y, Huang J.
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| J Biol Chem 285(2):935-42. doi: 10.1074/jbc.M109.051664. Epub 2009 Nov 6.
2010
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| 22 | CD34, MME
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| CD10 AND CD34 expression in childhood acute lymphoblastic leukemia in Morocco: clinical relevance and outcome.
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| Dakka N, Bellaoui H, Bouzid N, Khattab M, Bakri Y, Benjouad A.
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| Pediatr Hematol Oncol 26(4):216-31. 2009
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| 23 | IDE, MME
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| Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity.
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| Miners JS, Baig S, Tayler H, Kehoe PG, Love S.
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| J Neuropathol Exp Neurol 68(8):902-14. doi: 10.1097/NEN.0b013e3181afe475.
2009
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| 24 | MME
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| Estrogen regulation of the neprilysin gene through a hormone-responsive element.
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| Xiao ZM, Sun L, Liu YM, Zhang JJ, Huang J.
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| J Mol Neurosci 39(1-2):22-6. doi: 10.1007/s12031-008-9168-1. Epub 2009 Jan 6.
2009
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| 25 | MME, MMEL1
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| Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences.
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| Whyteside AR, Turner AJ.
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| FEBS Lett 582(16):2382-6. doi: 10.1016/j.febslet.2008.05.046. Epub 2008 Jun 6.
2008
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| 26 | MME
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| Neprilysin and amyloid beta peptide degradation.
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| Hersh LB, Rodgers DW.
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| Curr Alzheimer Res 5(2):225-31. Review.
2008
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| 27 | MME
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| Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
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| Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.
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| Am J Pathol 171(1):241-51.
2007
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| 28 | APP, MME
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| Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
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| Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.
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| Am J Pathol 171(1):241-51.
2007
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| 29 | PROL1, ANPEP, MME
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| Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.
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| Wisner A, Dufour E, Messaoudi M, Nejdi A, Marcel A, Ungeheuer MN, Rougeot C.
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| Proc Natl Acad Sci U S A 103(47):17979-84. Epub 2006 Nov 13. 2006
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| 30 | MME
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| Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2.
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| Goodman OB Jr, Febbraio M, Simantov R, Zheng R, Shen R, Silverstein RL, Nanus DM.
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| J Biol Chem 281(44):33597-605. Epub 2006 Aug 28.
2006
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| 31 | MME
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| Cell specific expression of CD10/neutral endopeptidase 24.11 gene in human prostatic tissue and cells.
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| Song J, Aumuller G, Xiao F, Wilhelm B, Albrecht M.
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| Prostate 58(4):394-405. 2004
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| 32 | MME
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| Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies.
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| Debiec H, Nauta J, Coulet F, van der Burg M, Guigonis V, Schurmans T, de Heer E, Soubrier F, Janssen F, Ronco P.
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| Lancet 364(9441):1252-9. 2004
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| 33 | MME
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| Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
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| Oefner C, D'Arcy A, Hennig M, Winkler FK, Dale GE.
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| J Mol Biol 296(2):341-9. 2000
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| 34 | MME
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| Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression.
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| Papandreou CN, Usmani B, Geng Y, Bogenrieder T, Freeman R, Wilk S, Finstad CL, Reuter VE, Powell CT, Scheinberg D, Magill C, Scher HI, Albino AP, Nanus DM.
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| Nat Med 4(1):50-7. 1998
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| 35 | ECE1, KEL, MME, PHEX
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| Mammalian membrane metallopeptidases : NEP, ECE, KELL and PEX.
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| Turner AJ, Tanzawa K.
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| FASEB J 11 : 355-364. 1997
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| 36 | MME
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| Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes.
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| Li C, et al.
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| Gene 164 : 363-366. 1995
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| 37 | MME
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| Jurkat T cells express a functional neutral endopeptidase activity (CALLA) involved in T cell activation.
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| Mari B, et al.
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| EMBO J 11 : 3875-3885. 1992
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| 38 | MME
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| The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27).
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| Barker PE, Shipp MA, D'Adamio L, Masteller EL, Reinherz EL.
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| J Immunol 142 : 283-287. 1989
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| 39 | MME
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| The common acute lymphoblastic leukemia antigen (neutral endopeptidase-3.4.24.11) gene is located on human chromosome 3.
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| Tran-Paterson R, et al.
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| Cancer Genet Cytogenet 42 : 129-134. 1989
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| 40 | MME
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| Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11) : multiple miniexons and separate 5' untranslated regions.
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| D'Adamio L, et al.
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| Proc Natl Acad Sci U S A 86 : 7103-7107. 1989
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| 41 | MME
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| Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).
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| Malfroy B, Kuang WJ, Seeburg PH, Mason AJ, Schofield PR.
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| FEBS Lett 229 : 206-210. 1988
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| 42 | MME
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| Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
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| Letarte M, et al.
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| J Exp Med 168 : 1247-1253. 1988
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| 43 | MME
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| Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.
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| Shipp MA, Richardson NE, Sayre PH, Brown NR, Masteller EL, Clayton LK, Ritz J, Reinherz EL.
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| Proc Natl Acad Sci U S A 85(13):4819-23. 1988
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| 44 | MME
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| Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells.
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| Carrel S, et al.
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| Eur J Immunol 12 : 354-357. 1982
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