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FLASH GENE

Symbol

MLX

contributors: - updated : 27-04-2006

HGNC name	MAX-like protein X
HGNC id	11645

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.1      Physical location : 40.719.077 - 40.725.220
Synonym name	transcription factor-like 4
Synonym symbol(s)	TCFL4, MAD7, MXD7

DNA

TYPE	functioning gene
STRUCTURE	6.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant alpha - splicing 2328 - 214 predominantly cytoplasmic Meroni variant beta - splicing 2418 - 244 predominantly cytoplasmic Meroni variant gamma - splicing 2580 33.3 298 predominantly nuclear Meroni

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	basic helix-loop-helix (HLH)
	leucine zipper domains

mono polymer

homomer , heteromer , dimer

HOMOLOGY

Homologene

FAMILY	basic helix-loop-helix (BHLH) family of transcription factors
	BHLH-ZIP subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION

basic FUNCTION

repressing transcription by recruiting the Sin3A-histone deacetylase corepressor complex

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	transcription repressor

PATHWAY

metabolism

signaling

a component	heterodimerize with MAD1,MAD4,MNT and WBSCR14
	homodimerize

INTERACTION

DNA	binding to 5'-CACGTG-3'

RNA

small molecule

protein	MAD1
	MAD4
	MNT
	WBSCR14
	MLXIP

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS