Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | MLH3 | contributors: mct - updated : 15-09-2016 |
HGNC name | mutL homolog 3 (E. coli) |
HGNC id | 7128 |
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Corresponding disease |
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Location | 14q24.3 Physical location : 75.480.466 - 75.518.235 | ||
Synonym name | DNA mismatch repair protein MLH3 | ||
Synonym symbol(s) | HNPCC7, MGC138372 |
DNA |
TYPE | functioning gene |
STRUCTURE | 34.00 kb 12 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | heteromer , dimer |
HOMOLOGY |
interspecies | homolog to yeast mutator gene (bacterial Mut L) |
Homologene |
FAMILY | DNA mismatch repair MUTl/HEXB family |
CATEGORY | DNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus |
CELLULAR PROCESS | nucleotide, repair, mismatch repair |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | heterodimer of MLH1 and MLH3 |
INTERACTION |
DNA |
RNA | MSH4 in meiotic cells |
small molecule |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | HNPCC7 |
Susceptibility |
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Variant & Polymorphism SNP | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |