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FLASH GENE
Symbol MLH3 contributors: mct - updated : 15-09-2016
HGNC name mutL homolog 3 (E. coli)
HGNC id 7128
ASSOCIATED DISORDERS
corresponding disease(s) HNPCC7
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral germinal mutation      
in colorectal cancer
tumoral     --low  
in low-grade glioma, by methylation of the promoter
Susceptibility
  • to colorectal cancer (in association with MLH1 mutation)
  • to male infertility
  • Variant & Polymorphism SNP
  • rs 175080 in the MLH3 gene associated to male infertility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS