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FLASH GENE
Symbol MINPP1 contributors: npt - updated : 23-01-2008
HGNC name multiple inositol polyphosphate histidine phosphatase, 1
HGNC id 7102
Location 10q23.3      Physical location : 89.264.222 - 89.313.217
Synonym name
  • Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
  • Ins(1,3,4,5)P(4) 3-phosphatase
    • Synonym symbol(s) MIPP, HIPER1, MINPP2, DKFZp564L2016
    EC.number 3.1.3.62
    DNA
    TYPE functioning gene
    STRUCTURE 48.49 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D17S1603 - D17S1579 /D17S1698 - D17S1687 - D17S579 /MINPP1 - D17S215 /D17S1765 - PTEN - D17S541 - qter
    Authors Chi (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2847 55 487 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved active site of histidine phosphatases
  • a C terminal consensus sequence, retaining the enzyme in the endoplasmic reticulum
    • HOMOLOGY
    interspecies homolog to murine Minpp1
    Homologene
    FAMILY
  • phosphoglycerate mutase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the tumorigenesis of at least a subset of malignant follicular thyroid
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation LOH    
    in follicular thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS