basic FUNCTION
| E3 ubiquitin ligase activity |
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auto-ubiquitination dependent on ATP, E1, E2 |
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may ubiquitylate TSG101 and regulate endosomal trafficking and thus be linked to spongiform neurodegeneration (Kim 2007) |
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might indirectly contribute to neurodegeneration, upon cytosolic exposure to prion protein the MGRN1 is functionally depleted (Chakrabati 2009) |
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decreasing MC1R and MC4R signaling to cAMP (Pérez-Oliva 2009) |
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might provide a novel athway for melanocortin signaling from the cell surface to the nucleus (Pérez-Oliva 2009) |
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role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the MC2R |