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FLASH GENE
Symbol MGRN1 contributors: SGE/npt - updated : 29-01-2014
HGNC name mahogunin, ring finger 1
HGNC id 20254
Location 16p13.3      Physical location : 4.674.825 - 4.740.974
Synonym name
  • RING finger protein 156
  • probable E3 ubiquitin-protein ligase MGRN1
  • Synonym symbol(s) RNF156, KIAA0544
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 66.15 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 6407 - 531 - -
  • isoform 4
  • 17 - 6470 - 552 - -
  • isoform 3
  • 17 - 3933 - 576 - -
  • isoform 1
  • 16 - 3870 - 555 - -
  • isoform 2
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines melanoma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C3HC4 type zinc finger
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Mgrn1 (90.9pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • all isoform are cytosolic, but exon12-containing isoforms are accumulated in the nuclei upon coexpression with the melanocortin receptors (Pérez-Oliva 2009)
  • basic FUNCTION
  • E3 ubiquitin ligase activity
  • auto-ubiquitination dependent on ATP, E1, E2
  • may ubiquitylate TSG101 and regulate endosomal trafficking and thus be linked to spongiform neurodegeneration (Kim 2007)
  • might indirectly contribute to neurodegeneration, upon cytosolic exposure to prion protein the MGRN1 is functionally depleted (Chakrabati 2009)
  • decreasing MC1R and MC4R signaling to cAMP (Pérez-Oliva 2009)
  • might provide a novel athway for melanocortin signaling from the cell surface to the nucleus (Pérez-Oliva 2009)
  • role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the MC2R
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
  • protein
  • interacting with the melanocortin receptors
  • in the presence of MGRN1 the MC2R is ubiquitinated and, after ACTH stimulation, evidence of multi-monoubiquitination appears
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) null mutant mice accumulate vacuoles throughout the brain that appear very similar to those associated with prion disease