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FLASH GENE
Symbol MEGF11 contributors: mct - updated : 31-10-2013
HGNC name MEGF11 protein
HGNC id 29635
Location 15q22.31      Physical location : 66.187.633 - 66.546.075
Synonym name
  • multiple epidermal growth factor-like domains protein 11
  • multiple EGF-like domains protein 11
  • Synonym symbol(s) KIAA1781, UNQ1949
    DNA
    TYPE functioning gene
    STRUCTURE 358.44 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094 MtFMT 15q22.2 methionyl-tRNA formyltransferase, mitochondrial OSTbeta 15q22.2 organic solute transporter beta RIS LOC390594 15 similar to RIKEN cDNA C230080I20 gene LOC390595 15 similar to ubiquitin associated protein PDCD7 15q22.2 programmed cell death 7 CLPX 15q22.31 ClpX caseinolytic protease X homolog (E. coli) CILP 15q22 cartilage intermediate layer protein, nucleotide pyrophosphohydrolase FLJ20509 15q22.2 hypothetical protein FLJ20509 LOC390596 15 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1; cell division cycle 2-like 1; PITSLRE protein kinase alpha; p58/GTA protein kinase; galactosyltransferase associated protein kinase; CDC-related protein kinase p5 PUNC 15q22.3-q23 putative neuronal cell adhesion molecule NOPE 15q22.2 putative neuronal cell adhesion molecule DPP8 15q22 dipeptidylpeptidase 8 HSPC121 15q22.2 butyrate-induced transcript 1 DKFZP564O1664 15q22.2 hypothetical protein DKFZp564O1664 SLC24A1 15q22 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 IRLB 15q22.2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 LOC388127 15 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) RAB11A 15q21.3-q22.31 RAB11A, member RAS oncogene family MEGF11 15q22.2 MEGF11 protein MGC4562 15q22.2 hypothetical protein MGC4562 FLJ20516 15q22.2 timeless-interacting protein MAP2K1 15q22.1-q22.33 mitogen-activated protein kinase kinase 1 LOC388128 15 similar to ribosomal protein L9; 60S ribosomal protein L9 SNAPC5 15q22.2 small nuclear RNA activating complex, polypeptide 5, 19kDa RPL4 15q22 ribosomal protein L4 FLJ10036 15q22.2 hypothetical protein FLJ10036 MADH6 15q21-q22 MAD, mothers against decapentaplegic homolog 6 (Drosophila) LOC390597 15 similar to leucine zipper-EF-hand containing transmembrane protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5914 - 1044 - 2012 2240732
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
     spinal cord    
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualamacrine cell Homo sapiens
    Visualhorizontal association cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells
  • is dispensable for starburst amacrine cells arrangement, but acts together with MEGf10 to shape the horizontal cells mosaic
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS