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FLASH GENE
Symbol MEGF11 contributors: mct - updated : 31-10-2013
HGNC name MEGF11 protein
HGNC id 29635
Location 15q22.31      Physical location : 66.187.633 - 66.546.075
Synonym name
  • multiple epidermal growth factor-like domains protein 11
  • multiple EGF-like domains protein 11
  • Synonym symbol(s) KIAA1781, UNQ1949
    DNA
    TYPE functioning gene
    STRUCTURE 358.44 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 5914 - 1044 - 2012 2240732
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
     spinal cord    
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualamacrine cell Homo sapiens
    Visualhorizontal association cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells
  • is dispensable for starburst amacrine cells arrangement, but acts together with MEGf10 to shape the horizontal cells mosaic
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS