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FLASH GENE
Symbol MEG3 contributors: mct/npt - updated : 22-04-2010
HGNC name maternally expressed 3 (non-protein coding)
HGNC id 14575
Corresponding disease
UPD14M chromosome 14 uniparental disomy, maternal
UPD14P chromosome 14 uniparental disomy, paternal
Location 14q32.2      Physical location : 101.292.444 - 101.327.358
Synonym name
  • gene TRAP locus 2
  • maternally expressed 3
  • non-protein coding RNA 23
  • very putative protein from MEG3 locus
  • Synonym symbol(s) GTL2, PRO0518, FLJ31163, FLJ42589, FP504, NCRNA00023, PRO0518, PRO2160
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 34.00 kb     9 Exon(s)
    regulatory sequence Promoter
    Binding site
    motif Viral sequence   gene pol
    text structure five CTCF binding sites around the promoter of MEG3 (CTCF-binding region may provide a mechanism for the transcriptional regulation of MEG3 and DLK1)
    MAPPING cloned Y linked N status provisional
    Map cen - DLK1 - MEG3 - RTL1 - MEG8 - TRCD0 - TRCD1 - TRCD2 - qter
    Authors Cavaille (02)
    Physical map
    BCL11B 14q32.31 B-cell CLL/lymphoma 11B (zinc finger protein) FLJ23027 14q32.32 hypothetical protein FLJ23027 CCNK 14q32 cyclin K C14orf136 14q32 chromosome 14 open reading frame 136 C14orf65 14q32.31 chromosome 14 open reading frame 65 LOC390506 14 similar to RIKEN cDNA E030025D05 gene KIAA1822 14q32 KIAA1822 CYP46A1 14q32.1 cytochrome P450, family 46, subfamily A, polypeptide 1 EML1 14q32 echinoderm microtubule associated protein like 1 LOC341965 14q32.32 similar to voltage-dependent anion channel 3 RPS2P3 14 ribosomal protein S2 pseudogene 3 EVL 14q32.32 Enah/Vasp-like C14orf66 14q32.32 chromosome 14 open reading frame 66 YY1 14q32.31-q32.32 YY1 transcription factor C14orf69 14q32.32 chromosome 14 open reading frame 69 C14orf68 14 chromosome 14 open reading frame 68 WARS 14q32.31 tryptophanyl-tRNA synthetase NDUFB3P4 14q NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 4 LOC388013 14 hypothetical gene supported by BX248767 MGC4645 14q32.32 hypothetical protein MGC4645 KIAA1446 14q32.32 brain-enriched guanylate kinase-associated protein LOC388014 14 LOC388014 DLK1 14q32 delta-like 1 homolog (Drosophila) MEG3 14q32 maternally expressed 3 LOC388015 14 similar to RTl1 LOC388016 14 LOC388016 LOC388017 14 LOC388017 LOC145197 14q32.32 hypothetical LOC145197 DIO3OS 14q32.33 deiodinase, iodothyronine, type III opposite strand DIO3 14q32 deiodinase, iodothyronine, type III LOC122423 14q32.33 similar to hypothetical protein ZC477.8 - Caenorhabditis elegans LOC388018 14 LOC388018 RPL26P4 14q32.34 ribosomal protein L26 pseudogene 3 C14orf72 14q32.33 chromosome 14 open reading frame 72 PPP2R5C 14q32.2 protein phosphatase 2, regulatory subunit B (B56), gamma isoform NPM1P20 14q32.33 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 20 DNCH1 14q32-qter dynein, cytoplasmic, heavy polypeptide 1 HSPCA 14q32.33 heat shock 90kDa protein 1, alpha WDR20 14q32.33 WD repeat domain 20 RAGE 14q32 renal tumor antigen C14orf131 14q32.33 chromosome 14 open reading frame 131 CINP 14q32.33 cyclin-dependent kinase 2-interacting protein KIAA0329 14q32-.11 cyclin-dependent kinase 2-interacting protein
    regionally located in DLK1-MEG3 (GTL2) reciprocally imprinted region
    RNA
    TRANSCRIPTS type untranslated
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING paternally
    text parent-specific methylation of sequences upstream of MEG3
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to synthenic to murine distal chromosome 12 Meg3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • suppressing tumor cell growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UPD14M , UPD14P
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancer
    tumoral        
    loss of expression in tumors
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia and myelodysplastic syndromes with worse overall prognosis (Benetatos 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS