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FLASH GENE
Symbol MEG3 contributors: mct/npt - updated : 22-04-2015
HGNC name maternally expressed 3 (non-protein coding)
HGNC id 14575
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to synthenic to murine distal chromosome 12 Meg3
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • suppressing tumor cell growth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region
  • reduced expression of MEG3 in liver cancer may activate PI3K/AKT pathway by inhibiting AP1G1 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UPD14M , UPD14P
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancer
    tumoral        
    loss of expression in tumors
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia and myelodysplastic syndromes with worse overall prognosis (Benetatos 2010)
    tumoral     --low  
    could promote the proliferative and invasive abilities of hepatoma cells and accelerate cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS