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FLASH GENE
Symbol MED8 contributors: npt/ - updated : 05-05-2006
HGNC name mediator complex subunit 8
HGNC id 19971
Location 1p34.2      Physical location : 43.849.587 - 43.855.483
Synonym name
  • mediator of RNA polymerase II transcription subunit MED8
  • mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)
  • activator-recruited cofactor 32 kDa component
    • Synonym symbol(s) MGC17544, MGC19641, ARC32
    DNA
    TYPE functioning gene
    STRUCTURE 5.90 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1193 29 268 - Brower (2002)
    8 - 1502 33 301 - Brower (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential Bc-box
    • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae mediator subunit med8p
    Homologene
    FAMILY
  • mediator complex subunit 8 family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • elongin BC interacting protein
  • recruiting ubiquitin ligase activity directly to the RNA polymerase II transcriptional machinery
    • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the mammalian mediator complex of RNA polymerase II transcription (Brower 2002)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • assembly with elongin BC,CUL2 and RRX1 to reconstitute an E3 ubiquitin ligase (Brower 2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS