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FLASH GENE
Symbol MED8 contributors: npt/ - updated : 05-05-2006
HGNC name mediator complex subunit 8
HGNC id 19971
DNA
TYPE functioning gene
STRUCTURE 5.90 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1193 29 268 - Brower (2002)
8 - 1502 33 301 - Brower (2002)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential Bc-box
    • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae mediator subunit med8p
    Homologene
    FAMILY
  • mediator complex subunit 8 family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • elongin BC interacting protein
  • recruiting ubiquitin ligase activity directly to the RNA polymerase II transcriptional machinery
    • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the mammalian mediator complex of RNA polymerase II transcription (Brower 2002)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • assembly with elongin BC,CUL2 and RRX1 to reconstitute an E3 ubiquitin ligase (Brower 2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS