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FLASH GENE
Symbol MDK contributors: - updated : 18-08-2007
HGNC name midkine (neurite growth-promoting factor 2)
HGNC id 6972
Location 11p11.2      Physical location : 46.402.617 - 46.405.374
Synonym name
  • heparin-binding growth factor
    • Synonym symbol(s) NEGF2, FLJ27379, MK
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure sequence activating transcroption of an exogenous suicide gene in pancreatic cancer
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC219638 11p11.2 similar to KIAA0543 protein SYT13 11p12-p11 synaptotagmin XIII CHST1 11p11.2-p11.1 carbohydrate (keratan sulfate GAL-6) sulfotransferase 1 DKFZp779M0652 11p11.2 hypothetical protein DKFZp779M0652 SLC35C1 11p11.2 solute carrier family 35, member C1 CRY2 11p12-q21.1 cryptochrome 2 (photolyase-like) MAPK8IP1 11p12-p11.2 mitogen-activated protein kinase 8 interacting protein 1 LOC143678 11p11.2 similar to RIKEN cDNA 1700021K07 PEX16 11p11.11 peroxisomal biogenesis factor 16 GYLTL1B 11p11.2 glycosyltransferase-like 1B BHC80 11p11.2 glycosyltransferase-like 1B CREB3L1 11p11.2 cAMP responsive element binding protein 3-like 1 DGKZ 11p11.2 diacylglycerol kinase, zeta 104kDa MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain MYBPC3 11p11.2 myosin binding protein C, cardiac SPI1 11p12 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SLC39A13 11p11.2 solute carrier family 39 (zinc transporter), member 13
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 909 - 143 - Mirkin
    - - 997 - 143 - Mirkin
    - - 866 - 143 - Mirkin
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines teratocarcinomas cell lines, pancreatic cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor a 121AA mature protein
    HOMOLOGY
    interspecies ortholog to murine Mk
    intraspecies homolog to NEGF1
    Homologene
    FAMILY pleiotrophin family
    CATEGORY adhesion , signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • essential for normal development of the catecholamine and renin-angiotensin pathways and the synthesis of different collagens
  • involved in nervous system development
  • mediator for intercellular transfer of drug resistance
  • promoting the migration of inflammatory leukocytes
  • playing important roles in the formation of intraperitoneal adhesions, at least partly by promoting the migration of macrophages and neutrophils to the omentum
  • implicated in the tumorigenesis of benign and plexiform neurofibromas, and therefore arising malignant peripheral nerve sheath tumors (MPNSTs)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text nervous tissue development and/or maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin
  • regulates PTN gene expression with a high degree of organ specificity
    • cell & other
    REGULATION
    induced by retinoic acid responsive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in sporadic colorectal and gastric cancer
    tumoral     --over  
    in hepatocellular carcinomas
    tumoral     --over  
    in malignant peripheral nerve sheath tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • specific inhibitors for MDK as part of new therapeutic concepts against MPNSTs (malignant peripheral nerve sheath tumor)
    • ANIMAL & CELL MODELS