| 1 | LTK, MDK
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| Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells.
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| Vieceli FM, Bronner ME.
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| Development 145(20). pii: dev164046. doi: 10.1242/dev.164046.
2018
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| 2 | MDK, VEGFA
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| Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3.
|
| Lautz T, Lasch M, Borgolte J, Troidl K, Pagel JI, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E.
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| EBioMedicine 27:237-246. doi: 10.1016/j.ebiom.2017.11.020. Epub 2017 Nov 26.
2018
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| 3 | MDK
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| Increased serum midkine levels in autism spectrum disorder patients.
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| Esnafoglu E, Cirrik S.
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| Int J Neurosci 128(7):677-681. doi: 10.1080/00207454.2017.1408620. Epub 2017 Dec 6.
2018
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| 4 | MDK
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| Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.
|
| Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.
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| Am J Pathol 187(4):740-751. doi: 10.1016/j.ajpath.2016.12.006. Epub 2017 Feb 7.
2017
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| 5 | MDK, PTN
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| Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus.
|
| Wu GC, Yuan H, Pan HF, Ye DQ.
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| Oncotarget 8(25):40181-40189. doi: 10.18632/oncotarget.13658.
2017
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| 6 | MDK
|
| Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.
|
| Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y.
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| Clin Exp Nephrol 21(4):597-607. doi: 10.1007/s10157-016-1318-0. Epub 2016 Aug 16.
2017
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| 7 | MDK
|
| Circulating midkine in children with Henoch-Schönlein purpura: Clinical implications.
|
| Su Z, Lv X, Liu Y, Zhang J, Guan J, Gai Z.
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| Int Immunopharmacol 39:246-250. doi: 10.1016/j.intimp.2016.07.032. Epub 2016 Aug 3. Erratum in: Int Immunopharmacol. 2016 Dec;41:145.
2016
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| 8 | MDK
|
| Circulating midkine in children with Henoch-Schönlein purpura: Clinical implications.
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| Su Z, Lv X, Liu Y, Zhang J, Guan J, Gai Z.
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| Int Immunopharmacol 39:246-250. doi: 10.1016/j.intimp.2016.07.032. Epub 2016 Aug 3. Erratum in: Int Immunopharmacol. 2016 Dec;41:145.
2016
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| 9 | MDK, PTN
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| Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies.
|
| Jee YH, Lebenthal Y, Chaemsaithong P, Yan G, Peran I, Wellstein A, Romero R, Baron J.
|
| PLoS One 11(4):e0153325. doi: 10.1371/journal.pone.0153325. eCollection 2016.
2016
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| 10 | MDK, PLSCR1
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| Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation.
|
| Slone EA, Pope MR, Fleming SD.
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| J Leukoc Biol 98(5):791-804. doi: 10.1189/jlb.3A1014-480R. Epub 2015 Jul 27. 2015
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| 11 | MDK, PLSCR1
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| Phospholipid Scramblase 1 Interacts with Midkine and Regulates Hepatic Cancer Cell Proliferation and Migration.
|
| Huang H, Lu Y, Min L, Jiang P, Dai L.
|
| Clin Lab 61(10):1501-8.
2015
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| 12 | MDK
|
| Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK).
|
| Luo J, Wang X, Xia Z, Yang L, Ding Z, Chen S, Lai B, Zhang N.
|
| Mol Biol Cell 26(3):430-9. doi: 10.1091/mbc.E14-10-1443. Epub 2014 Nov 26.
2015
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| 13 | MDK, PTN
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| Co-expression of midkine and pleiotrophin predicts poor survival in human glioma.
|
| Ma J, Lang B, Wang X, Wang L, Dong Y, Hu H.
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| J Clin Neurosci 21(11):1885-90. doi: 10.1016/j.jocn.2014.02.020. Epub 2014 Jul 4.
2014
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| 14 | MDK, SDC3
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| Midkine promotes perineural invasion in human pancreatic cancer.
|
| Yao J, Li WY, Li SG, Feng XS, Gao SG.
|
| World J Gastroenterol 20(11):3018-24. doi: 10.3748/wjg.v20.i11.3018.
2014
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| 15 | MDK
|
| The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18).
|
| Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Müller-Höcker J, Deindl E, Sperandio M, Walzog B.
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| Blood 123(12):1887-96. doi: 10.1182/blood-2013-06-510875. Epub 2014 Jan 23.
2014
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| 16 | MDK, NOTCH2
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| Midkine promotes neuroblastoma through Notch2 signaling.
|
| Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K.
|
| Cancer Res 73(4):1318-27. doi: 10.1158/0008-5472.CAN-12-3070. Epub 2012 Dec 14.
2013
|
| 17 | MDK
|
| Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.
|
| Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.
|
| Am J Pathol 182(2):410-9. doi: 10.1016/j.ajpath.2012.10.016. Epub 2012 Nov 27.
2013
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| 18 | MDK
|
| Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.
|
| Weckbach LT, Groesser L, Borgolte J, Pagel JI, Pogoda F, Schymeinsky J, Müller-Höcker J, Shakibaei M, Muramatsu T, Deindl E, Walzog B.
|
| Am J Physiol Heart Circ Physiol 303(4):H429-38. doi: 10.1152/ajpheart.00934.2011. Epub 2012 Jun 15.
2012
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| 19 | MDK
|
| Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.
|
| Sonobe Y, Li H, Jin S, Kishida S, Kadomatsu K, Takeuchi H, Mizuno T, Suzumura A.
|
| J Immunol 188(6):2602-11. doi: 10.4049/jimmunol.1102346. Epub 2012 Feb 8.
2012
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| 20 | MDK
|
| Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading.
|
| Liedert A, Mattausch L, Röntgen V, Blakytny R, Vogele D, Pahl M, Bindl R, Neunaber C, Schinke T, Harroch S, Amling M, Ignatius A.
|
| Bone 48(4):945-51. doi: 10.1016/j.bone.2010.12.019. Epub 2010 Dec 23.
2011
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| 21 | MDK
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| Increased trabecular bone formation in mice lacking the growth factor midkine.
|
| Neunaber C, Catala-Lehnen P, Beil FT, Marshall RP, Kanbach V, Baranowsky A, Lehmann W, Streichert T, Ignatius A, Muramatsu T, Schinke T, Amling M.
|
| J Bone Miner Res 25(8):1724-35. doi: 10.1002/jbmr.75.
2010
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| 22 | MDK
|
| Midkine gene transfer protects against focal brain ischemia and augments neurogenesis.
|
| Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M.
|
| J Neurol Sci 285(1-2):78-84. doi: 10.1016/j.jns.2009.05.026. Epub 2009 Jun 16.
2009
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| 23 | MDK
|
| Overexpression of Midkine promotes the viability of BA/F3 cells.
|
| Wang Y, Xing H, Tian Z, Tang K, Wang J, Xu Z, Rao Q, Wang M, Wang J.
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| Biochem Biophys Res Commun 384(3):341-6. doi: 10.1016/j.bbrc.2009.04.119. Epub 2009 May 4.
2009
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| 24 | MDK
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| Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.
|
| Huang Y, Hoque MO, Wu F, Trink B, Sidransky D, Ratovitski EA.
|
| Cell Cycle 7(11):1613-22. Epub 2008 Mar 16.
2008
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| 25 | MDK
|
| Expression of the heparin-binding growth factor midkine in the cerebrospinal fluid of patients with neurological disorders.
|
| Yoshida Y, Ikematsu S, Muramatsu H, Sakakima H, Mizuma N, Matsuda F, Sonoda K, Umehara F, Ohkubo R, Matsuura E, Goto M, Osame M, Muramatsu T.
|
| Intern Med 47(2):83-9. Epub 2008 Jan 15.
2008
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| 26 | MDK, PTN, SDC3
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| Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
|
| Marchionini DM, Lehrmann E, Chu Y, He B, Sortwell CE, Becker KG, Freed WJ, Kordower JH, Collier TJ.
|
| Brain Res 1147:77-88. Epub 2007 Feb 22.
2007
|
| 27 | MDK
|
| Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.
|
| Horiba M, Kadomatsu K, Yasui K, Lee JK, Takenaka H, Sumida A, Kamiya K, Chen S, Sakuma S, Muramatsu T, Kodama I.
|
| Circulation 114(16):1713-20. Epub 2006 Oct 2.
2006
|
| 28 | MDK
|
| Identification of midkine as a mediator for intercellular transfer of drug resistance.
|
| Mirkin BL, Clark S, Zheng X, Chu F, White BD, Greene M, Rebbaa A.
|
| Oncogene 24(31):4965-74. 2005
|
| 29 | PTN, MDK
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| Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family.
|
| Herradon G, Ezquerra L, Nguyen T, Silos-Santiago I, Deuel TF.
|
| Biochem Biophys Res Commun 333(3):714-21. 2005
|
| 30 | MDK
|
| Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency.
|
| Friedrich C, Holtkamp N, Cinatl J Jr, Sakuma S, Mautner VF, Wellman S, Michaelis M, Henze G, Kurtz A, Driever PH.
|
| Int J Oncol 27(5):1433-40. 2005
|
| 31 | MDK
|
| Midkine, a heparin-binding cytokine, plays key roles in intraperitoneal adhesions.
|
| Inoh K, Muramatsu H, Ochiai K, Torii S, Muramatsu T.
|
| Biochem Biophys Res Commun 317(1):108-13. 2004
|
| 32 | MDK
|
| A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer.
|
| Yoshida Y, Tomizawa M, Bahar R, Miyauchi M, Yamaguchi T, Saisho H, Kadomatsu K, Muramatsu T, Matsubara S, Sakiyama S, Tagawa M.
|
| Anticancer Res 22(1A):117-20. 2002
|
| 33 | MDK
|
| Molecular cloning, expression and purification of truncated midkine and its growth stimulatory activity on Wilms' tumor (G401) cells.
|
| Paul S, Mitsumoto T, Yamamoto I, Shinozawa T.
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| Cancer Lett 163(2):239-44. 2001
|
| 34 | MDK
|
| Genetic variations of the midkine (MK) gene in human sporadic colorectal and gastric cancers.
|
| Ahmed KM, Shitara Y, Kuwano H, Takenoshita S, Uchimuro K, Shinozawa T.
|
| Int J Mol Med 6(3):281-7. 2000
|
| 35 | MDK
|
| Expression of the midkine gene in human hepatocellular carcinomas.
|
| Koide N, Hada H, Shinji T, Ujike K, Hirasaki S, Yumoto Y, Hanafusa T, Kadomatsu K, Muramatsu H, Muramatsu T, Tsuji T.
|
| Hepatogastroenterology 46(30):3189-96. 1999
|
| 36 | MDK, PTN
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| Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man.
|
| O'Hara B, et al.
|
| Cytogenet Cell Genet 69 : 40-43. 1995
|
| 37 | MDK, PTN
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| Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant.
|
| Kretschmer PJ, et al.
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| Biochem Biophys Res Commun 192 : 420-429. 1993
|
| 38 | MDK
|
| Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization.
|
| Kaname T, et al.
|
| Genomics 17 : 514-515. 1993
|
| 39 | MDK
|
| A human gene family of neurite outgrowth-promoting proteins: heparin-binding neurite outgrowth promoting factor maps to 11p11-11p13.
|
| Eddy RL, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1958. 1991
|
| 40 | MDK, PTN
|
| Cloning, characterization, and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.
|
| Kretschmer PJ, et al.
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| Growth Factors 5 : 99-114. 1991
|
| 41 | MDK
|
| A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.
|
| Tsutsui J, Uehara K, Kadomatsu K, Matsubara S, Muramatsu T.
|
| Biochem Biophys Res Commun 176(2):792-7. 1991
|