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FLASH GENE
Symbol MDFI contributors: mct/npt - updated : 09-09-2004
HGNC name MyoD family inhibitor
HGNC id 6967
Location 6p21      Physical location : 41.606.194 - 41.621.981
Synonym name myogenic repressor I-mf
Synonym symbol(s) IMF, I-MF
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852 TREM1 6p21.1 triggering receptor expressed on myeloid cells 1 NCR2 6p21.1 natural cytotoxicity triggering receptor 2 FOXP4 6p21.1 forkhead box P4 MDFI 6p21 MyoD family inhibitor TFEB 6p21 transcription factor EB PGC 6p22-p12 progastricsin (pepsinogen C) FRS3 6p21.1 fibroblast growth factor receptor substrate 3 C6orf49 6p21.31 chromosome 6 open reading frame 49 MGC20741 6p21 ubiquitin specific protease 49 USP49 6p12.1 ubiquitin specific protease 49 BYSL 6p21.1 bystin-like CCND3 6p21 cyclin D3 TBN 6p21.1 taube nuss homolog (mouse) LOC389389 6 similar to hypothetical protein BC006605 GUCA1A 6p21.1 guanylate cyclase activator 1A (retina) GUCA1B 6p21.1 guanylate cyclase activator 1B (retina) MRPS10 6p21.1-p12.1 mitochondrial ribosomal protein S10 TRERF1 6p21.1-p12.1 transcriptional regulating factor 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1634 25 246 - Mizugishi (2004)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus  highly
 female systemplacenta  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text sclerotome
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine I-mfa
Homologene
FAMILY
  • myogenic factor D family (MYOD) inhibitor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • repressor of myogenic helix-loop-helix class transcription factors
  • involved in the patterning of somites
  • functions as a molecular switch to suppress the store dependence of TRPC1
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical and functional interaction with Zic proteins can play a role in the vertebrate development
  • physically interacts with TRPC1 (interaction is mediated by the C-terminal cytoplasmic tail of TRPC1 and the C-terminal cysteine-rich domain of MDFI)
  • interacting with TCF3 (inhibition of TCF3 binding )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS