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FLASH GENE
Symbol MDFI contributors: mct/npt - updated : 26-08-2019
HGNC name MyoD family inhibitor
HGNC id 6967
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1692 25 246 - 2017 28782576
6 - 1913 - 246 - 2017 28782576
5 - 1606 25 246 - 2017 28782576
4 - 1423 - 185 - 2017 28782576
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus  highly
 female systemplacenta  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text sclerotome
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal I-mfa domain
  • HOMOLOGY
    interspecies homolog to murine I-mfa
    Homologene
    FAMILY
  • myogenic factor D family (MYOD) inhibitor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • repressor of myogenic helix-loop-helix class transcription factors
  • involved in the patterning of somites
  • functions as a molecular switch to suppress the store dependence of TRPC1
  • MDFI and MDFIC interact with SERTA domain proteins SERTAD1, SERTAD2, SERTAD3, SERTAD4) and negatively regulate their transcriptional activity
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physical and functional interaction with Zic proteins can play a role in the vertebrate development
  • physically interacts with TRPC1 (interaction is mediated by the C-terminal cytoplasmic tail of TRPC1 and the C-terminal cysteine-rich domain of MDFI)
  • interacting with TCF3 (inhibition of TCF3 binding)
  • specifically interact with SERTAD1 through its C-terminal I-mfa domain
  • also specifically interacts with other SERTA domain-containing proteins, including SERTAD3 and SERTAD4, through its I-mfa domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly methylated in Colorectal cancer tissues when compared with adjacent normal colorectal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • with SSTR2, and CMTM3 having a potential role as biomarkers for colorectal cancer
  • association of higher methylation of the MDFI promoter with non-small cell lung carcinoma (NSCLC) may be specific to females, non-smokers and people aged &
  • 8804;65 years
    Therapy target
    ANIMAL & CELL MODELS