motifs/domains
| AAs 37-49 are a new PDCD6-binding domain  |
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one transmembrane helix |
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six predicted transmembrane domains |
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intracellular N- and C-terminus regions |
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two proline rich region |
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a consensus motif of lipases in first half of the protein |
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a bipartite nuclear localization signal(NLS) |
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six transmembrane-spanning domains with both amino- and carboxyl-terminal tails having a cytosolic orientation and the pore located between transmembrane segments 5 and 6, in C terminal half containing Ser(557), principal phosphorylation site and Ser(559) |
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two PKA (protein kinase A) consensus motifs |
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a 53-AA C-terminal region required for efficient exit from the Golgi |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| text
| translocated to the plasma membrane during lysosomal exocytosis |
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late endosomal and lysosomal ion channel protein |
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efficient lysosomal targeting requires di-leucine motifs in both the N-terminal and the C-terminal cytosolic tails |
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localized to later compartments along the endocytic pathway (late endosomes and lysosomes |
| basic FUNCTION
| late endosomal and lysosomal ion channel protein, involved in Ca2+ transport regulating lysosomal exocytosis and trafficking of late endosomes and lysosomes |
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involved in the acidification and in endosomal function |
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playing a major role in Ca(2+) transport regulating lysosomal exocytosis and potentially other phenomena related to the trafficking of late endosomes and lysosomes |
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functions as a Fe2+ permeable channel in late endosomes and lysosomes |
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correct localization of mucolipin-1 and the integrity of its ion pore are essential for its physiological function in the late endocytic pathway |
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with MCOLN2, dictate the localization of MCOLN3 and not vice versa |
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lysosomal membrane protein believed to play a role in endosomal-lysosomal interaction, lysosomal pH stability, lysosome maturation, lipid metabolism, and autophagy |
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activation of MCOLN1 in late endosome and lysosome may lead to the appearance of MCOLN1 proteins at the plasma membrane |
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has been suggested to regulate fusion/fission of vesicles in the endocytic pathway and/or some aspect of lysosomal ion homeostasis such as pH, iron, or zinc content |
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ion channel that regulates membrane transport along the endolysosomal pathway |
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releasing luminal Ca2+ mediated by MCOLN1 and promoting interaction with PDCD6 along with the PDCD6-dependent recruitment of other proteins implicated in fusion/fission events |
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involved in membrane remodeling and the formation of extensions suggests that it may play a role in the formation of cellular processes linked to the late endosome/lysosome (LE/L) pathway |
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mechanistic link between acute TRPML1 loss and cell death |
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potential role in zinc transport |
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lysosomal ion channel permeable to cations, including Fe2+ |
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redistributes potentially Fe2+ between the lysosomes and the cytoplasm |
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its role in the cell extends outside lysosomes |
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TMEM163 and MCOLN1 proteins play a critical role in cellular zinc homeostasis |
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lysosomal ion channel MCOLN1 and the poorly understood novel transporter TMEM163 have been shown to play a role in the Zn2+ uptake by the lysosomes |
