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FLASH GENE
Symbol MCM2 contributors: npt/mct/pgu - updated : 18-05-2016
HGNC name minichromosome maintenance complex component 2
HGNC id 6944
Location 3q21.3      Physical location : 127.317.252 - 127.341.274
Synonym name
  • MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)
  • cell division cycle, early S-phase-like 1
  • mitotin, cyclin like 1
  • DNA replication licensing factor MCM2
  • nuclear protein BM28
  • Synonym symbol(s) BM28, CDCL1, KIAA0030, CCNL1, MITOTIN, cdc19, D3S3194
    EC.number 3.6.4.12
    DNA
    TYPE functioning gene
    STRUCTURE 24.02 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC165622 3q21.2 similar to Alkaline sphingomyelinase LOC200810 3q21.2 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase LOC152015 3q21.2 similar to AKAP-binding sperm protein ropporin FLJ20473 FTHFD 3q21.2 formyltetrahydrofolate dehydrogenase KLF15 3q13-q21 Kruppel-like factor 15 FLJ40083 3q21.3 hypothetical protein FLJ40083 FLJ20123 3q21.3 hypothetical protein FLJ20123 MGC11349 3q21.3 hypothetical protein MGC11349 FLJ31300 3q21.3 hypothetical protein FLJ31300 CHST13 3q21.3 carbohydrate (chondroitin 4) sulfotransferase 13 MGC34728 3q21.3 hypothetical protein MGC34728 TXNRD3 3p13-q13.33 thioredoxin reductase 3 LOC255330 3q21.3 hypothetical protein LOC255330 LOC391571 3 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) MGC13016 DKFZp564A176 3q21.3 hypothetical protein DKFZp564A176 LOC285311 3q21.3 hypothetical gene supported by AK097460 TPRA40 3q21.2 seven transmembrane domain orphan receptor MCM2 3q21 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) PODLX2 15 endoglycan ABTB1 3q21 ankyrin repeat and BTB (POZ) domain containing 1 MGLL 3q21.3 monoglyceride lipase LOC166348 3q21.3 similar to RIKEN cDNA 4833415F11 SEC61A1 3q21.3 similar to RIKEN cDNA 4833415F11 RUVBL1 3q21 RuvB-like 1 (E. coli) SELB 3q21.3 elongation factor for selenoprotein translation LOC389146 3 LOC389146 DNAJB8 3q21.3 DnaJ (Hsp40) homolog, subfamily B, member 8 GATA2 3q21 GATA binding protein 2 LOC391572 3 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) GR6 3q21 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) FLJ40473 3q21.3 hypothetical protein FLJ40473 RPN1 3q21.3-q25.2 ribophorin I RAB7 3q21 RAB7, member RAS oncogene family LOC391573 3 similar to mKIAA1860 protein LOC391574 3 similar to MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MARK4 serine/threonine protein kinase LOC389147 3 similar to WD repeat domain 10 isoform 3 LOC391575 3 similar to Fat-specific protein FSP27 homolog ACAD9 3q21.3 acyl-Coenzyme A dehydrogenase family, member 9 KIAA1257 3q21.3 KIAA1257 protein FLJ12057 3q21.3 hypothetical protein FLJ12057 GP9 3q21 glycoprotein IX (platelet) LOC339122 KIAA1160 3q21.3 KIAA1160 protein ZNF9 3p13.3-q24 zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) COPG 3q21.3 coatomer protein complex, subunit gamma
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3453 - 904 - 1995 7842741
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus    
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal phosphorylation site (phosphorylation play functionally redundant but essential roles in initiation of DNA replication)
  • a MCM motif found in DNA-dependent ATPases required for the initiation of eukaryotic DNA replication
  • two MCM2 histone-binding domains (HBDs) required for MCM2-7 histone-chaperone function and normal cell proliferation
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm2 (minichromosome maintenance mutant)
    Homologene
    FAMILY
  • CDC family
  • MCM family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in an early step of DNA replication, participating in the cell cycle control of genome duplication
  • during S phase MCM2 functions as part of the replicative helicase but within the pre-replication, MCM2 is inactive
  • essential replicative helicase for DNA replication
  • is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain
  • likeky additional function for MCM2 outside its helicase function as a proper histone chaperone connected to the replication pathway
  • unique histone-binding mode of MCM2 thus endows the replicative helicase with ideal properties for recycling histones genome wide during DNA replication
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MCM2 binds to SNF8 and MCM2 competes with ELL for binding to SNF8 thus potentially modulating the stability of Holo-ELL complex
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression
  • MCM2 promoter is transcriptionally regulated by E2 and this transcription can be significantly inhibited by KLF15
  • role for CDC7 -mediated phosphorylation of MCM2 in the response to replicative stress, including some forms of DNA damage
  • CDC6, the licensing factor in replication, was positively regulated by CUL4B and contributed to the loading of MCM2 to chromatin
  • cell & other
    REGULATION
    activated by MYCN
    Phosphorylated by CDC7
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation might be involved in medulloblastoma tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • new prognostic proliferative marker in Wilms tumour
  • Therapy target
    ANIMAL & CELL MODELS