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FLASH GENE
Symbol MCM2 contributors: npt/mct/pgu - updated : 18-05-2016
HGNC name minichromosome maintenance complex component 2
HGNC id 6944
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal phosphorylation site (phosphorylation play functionally redundant but essential roles in initiation of DNA replication)
  • a MCM motif found in DNA-dependent ATPases required for the initiation of eukaryotic DNA replication
  • two MCM2 histone-binding domains (HBDs) required for MCM2-7 histone-chaperone function and normal cell proliferation
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm2 (minichromosome maintenance mutant)
    Homologene
    FAMILY
  • CDC family
  • MCM family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in an early step of DNA replication, participating in the cell cycle control of genome duplication
  • during S phase MCM2 functions as part of the replicative helicase but within the pre-replication, MCM2 is inactive
  • essential replicative helicase for DNA replication
  • is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain
  • likeky additional function for MCM2 outside its helicase function as a proper histone chaperone connected to the replication pathway
  • unique histone-binding mode of MCM2 thus endows the replicative helicase with ideal properties for recycling histones genome wide during DNA replication
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MCM2 binds to SNF8 and MCM2 competes with ELL for binding to SNF8 thus potentially modulating the stability of Holo-ELL complex
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression
  • MCM2 promoter is transcriptionally regulated by E2 and this transcription can be significantly inhibited by KLF15
  • role for CDC7 -mediated phosphorylation of MCM2 in the response to replicative stress, including some forms of DNA damage
  • CDC6, the licensing factor in replication, was positively regulated by CUL4B and contributed to the loading of MCM2 to chromatin
  • cell & other
    REGULATION
    activated by MYCN
    Phosphorylated by CDC7
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation might be involved in medulloblastoma tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • new prognostic proliferative marker in Wilms tumour
  • Therapy target
    ANIMAL & CELL MODELS