basic FUNCTION
| involved in an early step of DNA replication, participating in the cell cycle control of genome duplication |
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during S phase MCM2 functions as part of the replicative helicase but within the pre-replication, MCM2 is inactive |
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essential replicative helicase for DNA replication |
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is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain |
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likeky additional function for MCM2 outside its helicase function as a proper histone chaperone connected to the replication pathway |
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unique histone-binding mode of MCM2 thus endows the replicative helicase with ideal properties for recycling histones genome wide during DNA replication |