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FLASH GENE
Symbol MCIDAS contributors: mct - updated : 08-10-2014
HGNC name multiciliate differentiation and DNA synthesis associated cell cycle protein
HGNC id 40050
Location 5q11.2      Physical location : -
Synonym name
  • multicilin
  • Idas protein
  • Synonym symbol(s) IDAS, MCI, MCIN
    DNA
    TYPE functioning gene
    STRUCTURE 7.72 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2104 - 385 - 2011 21543332
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousplexus choroid     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal fragment (AAs 1127) containing the putative D-box domain,
  • a C-terminal fragment (AAs 131385), containing the coiled-coil domain, with a heptapeptide at the N-terminal end of the coiled coil (QYWKEVAE), also present in GMNN, and this part of Idas (residues 128385) is essential for the nuclear localization, consistent with the presence of two groups of basic AAs in positions 259264 and 301304 of the C-terminal part of the protein, that could function as a bipartite NLS
  • HOMOLOGY
    Homologene
    FAMILY Geminin superfamily
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • protein levels decrease in anaphase, whereas its overexpression causes mitotic defects
  • localize to the nucleus and is excluded from the nucleoli, exhibiting the same intracellular localization pattern as Geminin
  • localizes to the nucleus, where it directly activates the expression of genes required for multiciliate cell formation, including FOXJ1 and genes mediating centriole assembly
  • basic FUNCTION
  • coiled-coil protein related to Geminin
  • phylogenetically conserved coiled-coil protein with a sequence similarity to geminin
  • initiates multiciliate cell differentiation in diverse tissues, by coordinately promoting the transcriptional changes required for motile ciliogenesis and centriole assembly
  • MCI, GMNN, and GMNC may have arisen in vertebrates through duplication of an ancestral Geminin-like gene
  • is a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with GMNN through coiled-coil mediated interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GMNN binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development
  • GMNN and MCIDAS coiled coils preferentially form a heterodimer that inhibits GMNN function in DNA replication licensing
  • by coopting E2F4, E2F5 regulation of cell cycle genes, MCIDAS drives massive centriole assembly in epithelial progenitors in a manner required for multiciliate cell differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS