basic FUNCTION
| coiled-coil protein related to Geminin |
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phylogenetically conserved coiled-coil protein with a sequence similarity to geminin |
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initiates multiciliate cell differentiation in diverse tissues, by coordinately promoting the transcriptional changes required for motile ciliogenesis and centriole assembly |
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MCI, GMNN, and GMNC may have arisen in vertebrates through duplication of an ancestral Geminin-like gene |
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is a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation |
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MCIDAS and GMNC are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche |
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MCIDAS and GMNC/Lynkeas are key players on radial glial specification to ependymal cells |
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in the process of multi-ciliated cell (MCC) differentiation, MCIDAS, which activates the transcription of genes required for centriole formation during ciliogenesis, could partially restore MCCs in LARP6 morphants |
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GMNC and MCIDAS specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors to switch on a gene expression program leading to centriole amplification and cilia formation |
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implicated in the transcriptional regulation of multiciliated cells (MCCs) specification and differentiation |
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MCIDAS and activated E2F4 induce multiciliated cell differentiation in primary fibroblasts |
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mlticiliated cells (MCC) differentiation program is initiated by GMNC and MCIDAS, that activate key transcription factors, including TP73 and FOXJ1, to control the multiciliogenesis program |