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FLASH GENE
Symbol MCIDAS contributors: mct - updated : 15-09-2021
HGNC name multiciliate differentiation and DNA synthesis associated cell cycle protein
HGNC id 40050
Corresponding disease
ICS47 immotile cilia syndrome 47
Location 5q11.2      Physical location : -
Synonym name
  • multicilin
  • Idas protein
  • Synonym symbol(s) IDAS, MCI, MCIN, CILD42
    DNA
    TYPE functioning gene
    STRUCTURE 7.72 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2104 - 385 - 2011 21543332
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousplexus choroid     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal fragment (AAs 1–127) containing the putative D-box domain,
  • a C-terminal fragment (AAs 131–385), containing the coiled-coil domain, with a heptapeptide at the N-terminal end of the coiled coil (QYWKEVAE), also present in GMNN, and this part of Idas (residues 128–385) is essential for the nuclear localization, consistent with the presence of two groups of basic AAs in positions 259–264 and 301–304 of the C-terminal part of the protein, that could function as a bipartite NLS
  • HOMOLOGY
    Homologene
    FAMILY Geminin superfamily
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • protein levels decrease in anaphase, whereas its overexpression causes mitotic defects
  • localize to the nucleus and is excluded from the nucleoli, exhibiting the same intracellular localization pattern as Geminin
  • localizes to the nucleus, where it directly activates the expression of genes required for multiciliate cell formation, including FOXJ1 and genes mediating centriole assembly
  • basic FUNCTION
  • coiled-coil protein related to Geminin
  • phylogenetically conserved coiled-coil protein with a sequence similarity to geminin
  • initiates multiciliate cell differentiation in diverse tissues, by coordinately promoting the transcriptional changes required for motile ciliogenesis and centriole assembly
  • MCI, GMNN, and GMNC may have arisen in vertebrates through duplication of an ancestral Geminin-like gene
  • is a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation
  • MCIDAS and GMNC are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche
  • MCIDAS and GMNC/Lynkeas are key players on radial glial specification to ependymal cells
  • in the process of multi-ciliated cell (MCC) differentiation, MCIDAS, which activates the transcription of genes required for centriole formation during ciliogenesis, could partially restore MCCs in LARP6 morphants
  • GMNC and MCIDAS specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors to switch on a gene expression program leading to centriole amplification and cilia formation
  • implicated in the transcriptional regulation of multiciliated cells (MCCs) specification and differentiation
  • MCIDAS and activated E2F4 induce multiciliated cell differentiation in primary fibroblasts
  • mlticiliated cells (MCC) differentiation program is initiated by GMNC and MCIDAS, that activate key transcription factors, including TP73 and FOXJ1, to control the multiciliogenesis program
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with GMNN through coiled-coil mediated interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GMNN binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development
  • GMNN and MCIDAS coiled coils preferentially form a heterodimer that inhibits GMNN function in DNA replication licensing
  • by coopting E2F4, E2F5 regulation of cell cycle genes, MCIDAS drives massive centriole assembly in epithelial progenitors in a manner required for multiciliate cell differentiation
  • TP73 acts upstream of FOXJ1 and downstream of MCIDAS
  • is a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation
  • GMNC directly transactivates the MCIDAS and FOXJ1 upstream regulatory sequences, and its activity is enhanced by E2F5 and inhibited by Geminin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS47
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS